Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 4/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935953 | 0.98 | CHRNB2 (0.57) | CHRNB2CHRNA4KDM4EPOLBGAA | |
| SCHEMBL2934355 | 0.93 | L3MBTL1 (0.56) | CHRNB2CHRNA4KDM4EATML3MBTL1 | |
| SCHEMBL15884247 | 0.91 | L3MBTL1 (0.54) | CHRNB2CHRNA4KDM4EATML3MBTL1 | |
| SCHEMBL2936683 | 0.87 | CHRNB2 (0.51) | CHRNB2CHRNA4KDM4ELTA4HPTGS2 | |
| SCHEMBL3577214 | 0.85 | TSHR (0.55) | CHRNB2CHRNA4KDM4ELTA4HALDH1A1 | |
| SCHEMBL15884244 | 0.80 | CHRNB2 (0.57) | CHRNB2CHRNA4LTA4HPTGS2PSMB1 | |
| SCHEMBL18474493 | 0.80 | CHRNB2 (0.57) | CHRNB2CHRNA4KDM4ELTA4HPTGS2 | |
| SCHEMBL15884439 | 0.78 | HRH3 (0.54) | KDM4EHRH3ALDH1A1KCNH2 | |
| Hydrochloric Acid SCHEMBL7669872 | 0.78 | CHRNB2 (0.51) | CHRNB2CHRNA4GAAL3MBTL1 | |
| SCHEMBL7097968 | 0.77 | CHRNB2 (0.66) | CHRNB2CHRNA4KDM4ELTA4HPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |