SCHEMBL29344715

SCHEMBL29344715

Cc1cc(Cl)nc2ccnn12

nearest known ligand 0.67

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 2/20 0.67
KCNN3 Q9UGI6 14/20 0.50
KCNN1 Q92952 2/20 0.49
KCNN2 Q9H2S1 2/20 0.49
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CCNT1 O60563 2/20 0.33
CDK9 P50750 2/20 0.33
CRHR1 P34998 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3460690 0.80 PIK3CG (0.48) PDE10ANPC1RAB9A
SCHEMBL29869 0.80 PDE10A (1.00) PDE10AKCNN3KCNN1KCNN2
SCHEMBL30974 0.77 PDE10A (0.67) PDE10AKCNN3KCNN1KCNN2
SCHEMBL1290450 0.77 PDE10A (0.67) PDE10AKCNN3KCNN1KCNN2
SCHEMBL13073900 0.77 PDE10A (0.43) PDE10AKCNN3KCNN1KCNN2CCNT1
SCHEMBL20664459 0.77 PDE10A (0.43) PDE10AKCNN3KCNN1KCNN2NPC1
SCHEMBL9300367 0.77 PDE10A (0.43) PDE10AKCNN3KCNN1KCNN2CCNT1
SCHEMBL13624090 0.77 PDE10A (0.61) PDE10AKCNN3KCNN1KCNN2CCNT1
SCHEMBL14158199 0.77 PDE10A (0.61) PDE10AKCNN3KCNN1KCNN2CCNT1
SCHEMBL14013844 0.77 PDE10A (0.61) PDE10AKCNN3KCNN1KCNN2CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151992-A1 PREPARATION OF A TYK2 INHIBITOR VENTYX BIOSCIENCES, INC. (US) 2024-07-18 WO disclosed