Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348124 | 0.96 | MEN1 (0.43) | KMT2AMEN1TP53RXFP1AKR1B1 | |
| SCHEMBL29348116 | 0.88 | NLRP3 (0.46) | KMT2ATP53RXFP1SMN1; SMN2TSHR | |
| SCHEMBL29348106 | 0.86 | NLRP3 (0.47) | KMT2ATP53AKR1B1SMN1; SMN2TSHR | |
| SCHEMBL24077029 | 0.83 | MEN1 (0.44) | KMT2AMEN1TP53RXFP1AKR1B1 | |
| SCHEMBL29348127 | 0.82 | NLRP3 (0.46) | KMT2AMEN1TP53RXFP1AKR1B1 | |
| SCHEMBL29348083 | 0.80 | S1PR2 (0.46) | KMT2AMEN1AKR1B1SMN1; SMN2TSHR | |
| SCHEMBL29348084 | 0.75 | KMO (0.46) | KMT2AMEN1AKR1B1S1PR2MAT2A | |
| SCHEMBL29348120 | 0.75 | NLRP3 (0.53) | KMT2AMEN1TP53RXFP1AKR1B1 | |
| SCHEMBL29348074 | 0.74 | GAA (0.51) | KMT2AMEN1RXFP1SMN1; SMN2TSHR | |
| SCHEMBL29348119 | 0.74 | NLRP3 (0.52) | KMT2AMEN1TP53RXFP1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239757-A1 | PHTHALAZINONE DERIVATES AS NLRP3 INFLAMMASOME INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239757-A1 | PHTHALAZINONE DERIVATES AS NLRP3 INFLAMMASOME INHIBITORS | NLRP3, NLRP1, PYCARD | KMT2A 1964/4885MEN1 2642/4885TP53 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.