Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29348119 | 0.96 | NLRP3 (0.52) | NLRP3CHRNA7MEN1KMT2ATHRB | |
| SCHEMBL29348114 | 0.85 | NLRP3 (0.52) | NLRP3CHRNA7THRBTP53RAB9A | |
| SCHEMBL24077040 | 0.83 | CHRNA7 (0.50) | NLRP3CHRNA7MEN1KMT2ATHRB | |
| SCHEMBL24077114 | 0.83 | NLRP3 (0.51) | NLRP3CHRNA7MEN1KMT2AMDM2 | |
| SCHEMBL29348105 | 0.82 | NLRP3 (0.50) | NLRP3CHRNA7GPR139 | |
| SCHEMBL29348084 | 0.79 | KMO (0.46) | MEN1KMT2ARAB9A | |
| SCHEMBL24077401 | 0.76 | NLRP3 (0.54) | NLRP3CHRNA7MEN1KMT2ATHRB | |
| SCHEMBL24077051 | 0.76 | NLRP3 (0.53) | NLRP3CHRNA7THRBTP53RAB9A | |
| SCHEMBL31305730 | 0.75 | TP53 (0.54) | NLRP3CHRNA7THRBTP53RAB9A | |
| SCHEMBL29348083 | 0.74 | S1PR2 (0.46) | MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239757-A1 | PHTHALAZINONE DERIVATES AS NLRP3 INFLAMMASOME INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239757-A1 | PHTHALAZINONE DERIVATES AS NLRP3 INFLAMMASOME INHIBITORS | NLRP3, NLRP1, PYCARD | NLRP3 1/4885CHRNA7 4614/4885MEN1 2642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.