Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31068201 | 1.00 | KMT2A (0.41) | KMT2ANPSR1MEN1ALDH1A1RECQL | |
| SCHEMBL29348412 | 0.85 | CREBBP (0.48) | KMT2AMEN1ALDH1A1DDB1CRBN | |
| SCHEMBL29348783 | 0.84 | CREBBP (0.47) | KMT2AMEN1ALDH1A1DDB1CRBN | |
| SCHEMBL31068121 | 0.84 | CREBBP (0.47) | KMT2AMEN1ALDH1A1DDB1CRBN | |
| SCHEMBL31068101 | 0.83 | PRKAB2 (0.39) | ALDH1A1DDB1CRBNNPC1SMN1; SMN2 | |
| SCHEMBL29348461 | 0.83 | PRKAB2 (0.39) | ALDH1A1DDB1CRBNNPC1SMN1; SMN2 | |
| SCHEMBL29348366 | 0.80 | DDB1 (0.49) | ALDH1A1DDB1CRBN | |
| SCHEMBL31068093 | 0.80 | BRD4 (0.45) | ALDH1A1DDB1CRBN | |
| SCHEMBL29348361 | 0.80 | DDB1 (0.46) | ALDH1A1DDB1CRBN | |
| SCHEMBL31068228 | 0.79 | ROCK1 (0.46) | KMT2AMEN1DDB1CRBNRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151547-A1 | TARGETED DEGRADATION OF VAV1 | MONTE ROSA THERAPEUTICS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |