SCHEMBL29350985

SCHEMBL29350985

c1csc(-c2nnc(-c3cccs3)c3nccnc23)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK5 Q00535 2/20 0.45
CDK5R1 Q15078 2/20 0.45
RPS6KB2 Q9UBS0 2/20 0.44
CYP2E1 P05181 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2A6 P11509 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2B6 P20813 1/20 0.42
DHFR P00374 1/20 0.42
CCNB2 O95067 1/20 0.42
CDK1 P06493 1/20 0.42
CCNB1 P14635 1/20 0.42
GSK3B P49841 1/20 0.42
CCNB3 Q8WWL7 1/20 0.42
ALDH1A1 P00352 5/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
KDM4E B2RXH2 3/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29350983 1.00 CDK5 (0.45) CDK5CDK5R1RPS6KB2CYP2E1CYP3A4
SCHEMBL29351028 0.89 CDK5 (0.39) CDK5CDK5R1RPS6KB2CYP2E1CYP3A4
SCHEMBL28697652 0.89 ADORA2A (0.43) CDK5CDK5R1RPS6KB2CYP2E1CYP3A4
SCHEMBL28673333 0.85 SMN1; SMN2 (0.37) CDK5CDK5R1RPS6KB2CYP2E1CYP3A4
SCHEMBL29349636 0.85 ALDH1A1 (0.40) CDK5CDK5R1RPS6KB2CYP3A4CYP2C9
SCHEMBL20837416 0.78 CYP3A4 (0.45) CDK5CDK5R1RPS6KB2CYP2E1CYP3A4
SCHEMBL30679242 0.77 CDK5 (0.51) CDK5CDK5R1RPS6KB2CYP2E1CYP3A4
SCHEMBL2237236 0.77 GLO1 (0.47) CDK5CDK5R1CYP2E1CYP3A4CYP2A6
SCHEMBL29352356 0.76 RPS6KB2 (0.46) CDK5CDK5R1RPS6KB2CYP3A4CYP2C9
SCHEMBL9927348 0.75 MEN1 (0.46) CDK5CDK5R1CYP2E1CYP3A4CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113956295-A Iridium metal complex, application thereof and organic electroluminescent device 清华大学 2022-01-21 CN disclosed