Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.57 |
| ▸ | GLS | O94925 | 10/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18352279 | 0.83 | MAPK14 (0.58) | MAPK14ROCK1ROCK2GLSABCB1 | |
| SCHEMBL29351167 | 0.83 | MAPK14 (0.58) | MAPK14ROCK1ROCK2GLSABCB1 | |
| SCHEMBL27913707 | 0.76 | ROCK2 (0.87) | MAPK14ROCK1ROCK2MMP13NAMPT | |
| SCHEMBL14256086 | 0.76 | MAPK14 (0.62) | MAPK14ROCK1ROCK2GLSABCB1 | |
| SCHEMBL19558998 | 0.76 | MAPK14 (0.58) | MAPK14ROCK1ROCK2GLSABCB1 | |
| SCHEMBL3608651 | 0.75 | ROCK1 (0.60) | MAPK14ROCK1ROCK2GLSABCB1 | |
| SCHEMBL5724446 | 0.75 | MAPK14 (0.63) | MAPK14ROCK1ROCK2GLSMMP13 | |
| SCHEMBL13647056 | 0.75 | MAPK14 (0.63) | MAPK14ROCK1ROCK2GLSABCB1 | |
| SCHEMBL19558993 | 0.74 | GLS (0.69) | MAPK14ROCK1ROCK2GLS | |
| SCHEMBL23195276 | 0.74 | MAPK14 (0.65) | MAPK14ROCK1ROCK2GLSABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107921044-B | GLS1 inhibitors for the treatment of disease | 德州大学系统董事会 | 2022-01-21 | — | — | CN | disclosed |