Bufotenine

Bufotenine

SCHEMBL29353068

CN(C)CCc1c[nH]c2ccc(O)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 9/20 1.00
HTR1A P08908 8/20 1.00
HTR2A P28223 7/20 1.00
SLC6A4 P31645 2/20 1.00
HTR2B P41595 6/20 0.78
HTR1D P28221 11/20 0.74
MPO P05164 1/20 0.68
HTR1B P28222 7/20 0.67
HTR3E A5X5Y0 3/20 0.65
HTR3B O95264 3/20 0.65
HTR1E P28566 3/20 0.65
HTR1F P30939 3/20 0.65
HTR7 P34969 3/20 0.65
HTR3A P46098 3/20 0.65
HTR5A P47898 3/20 0.65
HTR6 P50406 3/20 0.65
HTR4 Q13639 3/20 0.65
HTR3D Q70Z44 3/20 0.65
HTR3C Q8WXA8 3/20 0.65
CYP2D6 P10635 3/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bufotenine SCHEMBL518028 1.00 HTR2C (1.00) HTR2CHTR1AHTR2ASLC6A4HTR2B
Bufotenine SCHEMBL5832731 0.93 HTR1A (0.86) HTR2CHTR1AHTR2ASLC6A4HTR2B
SCHEMBL31041081 0.88 HTR2C (1.00) HTR2CHTR1AHTR2ASLC6A4HTR2B
SCHEMBL21846788 0.87 HTR1D (0.77) HTR2CHTR1AHTR2ASLC6A4HTR2B
SCHEMBL23069145 0.85 HTR1D (0.78) HTR2CHTR1AHTR2ASLC6A4HTR2B
SCHEMBL21333441 0.85 HTR2C (0.74) HTR2CHTR1AHTR2ASLC6A4HTR2B
Bufotenine SCHEMBL31098272 0.85 HTR2C (0.74) HTR2CHTR1AHTR2ASLC6A4HTR2B
SCHEMBL23069123 0.85 HTR1D (1.00) HTR2CHTR1AHTR2ASLC6A4HTR2B
SCHEMBL23069161 0.84 HTR2C (0.72) HTR2CHTR1AHTR2ASLC6A4HTR2B
SCHEMBL8891077 0.84 HTR1D (1.00) HTR2CHTR1AHTR2ASLC6A4HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260090957-A1 Process for making aqueous therapeutic particle having stable exterior water clustering with nanosized thickness DRESDNER JR KARL P (US) 2026-04-02 US claimed
WO-2025099725-A1 CONJUGATES AND USES THEREOF HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) 2025-05-15 WO claimed
EP-4547250-A1 METHODS AND COMPOSITIONS RELATING TO CONTROLLING PSYCHEDELIC EFFECTS WITH SEROTONIN RECEPTOR MODULATORS Terran Biosciences Inc. (US) 2025-05-07 EP claimed
EP-4313030-A1 METHODS AND COMPOSITIONS RELATING TO PSYCHEDELICS AND SEROTONIN RECEPTOR MODULATORS Terran Biosciences, Inc. (US) 2024-02-07 EP claimed
WO-2024006984-A1 METHODS AND COMPOSITIONS RELATING TO CONTROLLING PSYCHEDELIC EFFECTS WITH SEROTONIN RECEPTOR MODULATORS TERRAN BIOSCIENCES INC. (US) 2024-01-04 WO claimed
WO-2022212854-A1 METHODS AND COMPOSITIONS RELATING TO PSYCHEDELICS AND SEROTONIN RECEPTOR MODULATORS TERRAN BIOSCIENCES INC. (US) 2022-10-06 WO claimed
CN-122005549-A Application of indole alkali compound in preparation of medicine or skin care product for treating or preventing skin diseases 南京效真生物科技有限公司 2026-05-12 CN disclosed
US-20250339403-A1 Tryptamine Formulations and Uses Thereof Natural MedTech Pty Ltd (AU) 2025-11-06 US disclosed
EP-4640256-A2 MIST INHALER DEVICES FOR THERAPEUTIC DELIVERY Shaheen Innovations Holding Limited (AE) 2025-10-29 EP disclosed
EP-4638757-A1 METHODS FOR THE PRODUCTION OF TRYPTOPHAN DERIVATIVES Natural Medtech Pty Ltd (AU) 2025-10-29 EP disclosed
EP-4615444-A1 TRYPTAMINE FORMULATIONS AND USES THEREOF Natural Medtech Pty Ltd (AU) 2025-09-17 EP disclosed
EP-4615414-A1 ORALLY ADMINISTRABLE FORMULATION Greenspoon, Allen (CA) 2025-09-17 EP disclosed
EP-4608482-A1 MULTI-CHAMBER MIST GENERATOR FOR GENERATING MIST INCLUDING A THERAPEUTIC Shaheen Innovations Holding Limited (AE) 2025-09-03 EP disclosed
CN-114727934-A Wound debridement system 雷杰尼斯有限公司 2022-07-08 CN disclosed
WO-2022115798-A2 COMPOSITIONS AND METHODS FOR TREATING MIGRAINE WESANA HEALTH INC. (US) 2022-06-02 WO disclosed
WO-2022115796-A1 COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL CONDITIONS WESANA HEALTH INC. (US) 2022-06-02 WO disclosed
WO-2022099424-A1 ENGINEERED MICROORGANISMS FOR PRODUCING SUBSTITUTED TRYPTAMINES ALGAE-C INC. (CA) 2022-05-19 WO disclosed
EP-3994458-A1 ARYLALKYLAMINE, PYRROLE, INDOLE AND OPIATE DERIVATIVE CONCENTRATION DETERMINATION METHOD AND TEST KIT USING SAID METHOD Blei, Felix (DE) 2022-05-11 EP disclosed
WO-2022081631-A1 GPCR SCREENING METHOD TO IDENTIFY NON-HALLUCINOGENIC COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-04-21 WO disclosed
CN-113956188-A Synthesis method of N, N-dimethyl-5-methoxytryptamine 河北维达康生物科技有限公司 2022-01-21 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260090957-A1 Process for making aqueous therapeutic particle having stable exterior water clustering with nanosized thickness QPCT, SLC38A7, QPCTL HTR2C 1076/4885HTR1A 2572/4885HTR2A 2610/4885
US-20250339403-A1 Tryptamine Formulations and Uses Thereof MAOA, MAOB, TPH1 HTR2C 33/4885HTR1A 15/4885HTR2A 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.