Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HPRT1 | P00492 | 5/20 | 0.35 |
| ▸ | DHFR | P00374 | 5/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | POLG | P54098 | 2/20 | 0.33 |
| ▸ | POLA1 | P09884 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL230712 | 0.90 | CASP7 (0.54) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL3721701 | 0.85 | KDM4E (0.46) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL25433714 | 0.84 | CASP7 (0.49) | KDM4EMEN1RGS12LMNACYP3A4 | |
| Pyrophosphoric Acid SCHEMBL381155 | 0.79 | KDM4E (0.30) | KDM4EMEN1RGS12LMNACYP3A4 | |
| 7,8-Dihydropteroate SCHEMBL25432562 | 0.78 | KDM4E (0.41) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL9152033 | 0.74 | CASP7 (0.52) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL381157 | 0.74 | — | — | |
| SCHEMBL31338610 | 0.72 | CASP7 (0.48) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL1533829 | 0.71 | KDM4E (0.45) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL7077068 | 0.71 | CASP7 (0.58) | KDM4EMEN1RGS12LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260021148-A1 | METHODS FOR ENHANCING IMMUNE CHECKPOINT BLOCKADE THERAPY BY MODULATING THE MICROBIOME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2026-01-22 | — | — | US | disclosed |
| US-20250207207-A1 | TAXONOMIC SIGNATURES AND METHODS OF DETERMINING THE SAME | BAYLOR COLLEGE OF MEDICINE (US) | 2025-06-26 | — | — | US | disclosed |
| US-12318413-B2 | Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2025-06-03 | — | — | US | disclosed |
| US-12310996-B2 | Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2025-05-27 | — | — | US | disclosed |
| CN-118660711-A | Methods and compositions for predicting cancer survival and CAR T cytotoxicity | 纪念斯隆-凯特琳癌症中心 | 2024-09-17 | — | — | CN | disclosed |
| EP-4426324-A1 | METHODS AND COMPOSITIONS FOR PREDICTING CANCER SURVIVAL AND CAR T CELL TOXICITY | Memorial Sloan Kettering Cancer Center (US) | 2024-09-11 | — | — | EP | disclosed |
| US-20240293481-A1 | METHODS AND COMPOSITIONS FOR PREDICTING CANCER SURVIVAL AND CAR T CELL TOXICITY | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2024-09-05 | — | — | US | disclosed |
| US-20240173361-A1 | METHODS FOR ENHANCING IMMUNE CHECKPOINT BLOCKADE THERAPY BY MODULATING THE MICROBIOME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-05-30 | — | — | US | disclosed |
| CN-114286858-B | Folic acid producing strain, and preparation and application thereof | 赤峰制药股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| US-20230233620-A1 | HIGH-COMPLEXITY SYNTHETIC GUT BACTERIAL COMMUNITIES | Kanvas Biosciences, Inc. | 2023-07-27 | — | — | US | disclosed |
| CN-116096881-A | Microorganism producing 5-methyl folate | 赤峰制药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| US-20230109343-A1 | METHODS FOR ENHANCING IMMUNE CHECKPOINT BLOCKADE THERAPY BY MODULATING THE MICROBIOME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-04-06 | — | — | US | disclosed |
| US-11395838-B2 | Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-07-26 | — | — | US | disclosed |
| EP-4017959-A1 | FOLATE PRODUCING STRAIN AND THE PREPARATION AND APPLICATION THEREOF | Chifeng Pharmaceutical Co., Ltd (CN) | 2022-06-29 | — | — | EP | disclosed |
| CN-114286858-A | Folic acid producing strain and preparation and application thereof | 赤峰制药股份有限公司 | 2022-04-05 | — | — | CN | disclosed |
| US-20220081708-A1 | DIAGNOSIS AND TREATMENT OF DYSBIOSIS-ASSOCIATED WITH NEC | Infinant Health, Inc | 2022-03-17 | — | — | US | disclosed |
| US-20200129569-A1 | METHODS FOR ENHANCING IMMUNE CHECKPOINT BLOCKADE THERAPY BY MODULATING THE MICROBIOME | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2020-04-30 | — | — | US | disclosed |
| CN-105137086-A | Kit and test strip for detecting sulfonamides and use thereof | UNIV CHINA AGRICULTURAL | 2015-12-09 | — | — | CN | disclosed |
| CN-105018406-A | Recombinant Escherichia coli for producing protein capable of detecting sulfonamide as well as construction method and application of recombinant Escherichia coli | UNIV CHINA AGRICULTURAL | 2015-11-04 | — | — | CN | disclosed |
| EP-2230312-A1 | Probe compound for detecting and isolating enzymes and means and methods using the same | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2010-09-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260021148-A1 | METHODS FOR ENHANCING IMMUNE CHECKPOINT BLOCKADE THERAPY BY MODULATING THE MICROBIOME | PDCD1, CD274, PDCD1LG2 | KDM4E 254/4885MEN1 1246/4885RGS12 3532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.