Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 2/20 | 0.40 |
| ▸ | POLG | P54098 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | POLA1 | P09884 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.32 |
| ▸ | DHFR | P00374 | 3/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrophosphoric Acid SCHEMBL2935409 | 0.85 | KDM4E (0.49) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL3721707 | 0.82 | PNP (0.38) | PNPPOLGPOLBPOLA1 | |
| SCHEMBL381156 | 0.81 | — | — | |
| SCHEMBL1533829 | 0.77 | KDM4E (0.45) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL230712 | 0.76 | CASP7 (0.54) | KDM4EMEN1RGS12LMNACYP3A4 | |
| 7,8-Dihydropteroate SCHEMBL25432562 | 0.73 | KDM4E (0.41) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL31338610 | 0.72 | CASP7 (0.48) | KDM4EMEN1RGS12LMNACYP3A4 | |
| Triphosphate SCHEMBL3343310 | 0.71 | PNP (0.40) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL25433714 | 0.71 | CASP7 (0.49) | KDM4EMEN1RGS12LMNACYP3A4 | |
| SCHEMBL7077068 | 0.69 | CASP7 (0.58) | KDM4EMEN1RGS12LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116240188-A | Preparation method of dihydropteroic acid synthetase mutant with improved thermal stability | 中国农业大学 | 2023-06-09 | — | — | CN | claimed |
| CN-112961878-B | Application of lactobacillus plantarum gene in folic acid biological generation | 昆明理工大学 | 2023-04-25 | — | — | CN | claimed |
| US-20060088900-A1 | Method for determining inhibition activity of a compound on one of the enzymes of the folate synthesis pathway | AVENTIS PHARMA S.A. (FR) | 2006-04-27 | — | — | US | claimed |
| EP-1281769-A1 | Screening-method for inhibitors of folate-synthesis-pathway enzymes | Aventis Pharma S.A. (FR) | 2003-02-05 | — | — | EP | claimed |
| CN-116240188-B | Preparation method of dihydropteroic acid synthetase mutant with improved thermal stability | 中国农业大学 | 2026-04-07 | — | — | CN | disclosed |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | WASHINGTON UNIVERISTY (US) | 2025-09-23 | — | — | US | disclosed |
| US-20240390433-A1 | GENETICALLY MODIFIED BACILLUS SUBTILIS STRAIN AND USE AS A LIVE DELIVERY AND PRODUCTION SYSTEM | BIOMEDIT, INC. | 2024-11-28 | — | — | US | disclosed |
| EP-4387638-A1 | GENETICALLY MODIFIED BACILLUS SUBTILIS STRAIN AND USE AS A LIVE DELIVERY AND PRODUCTION SYSTEM | BiomEdit, LLC (US) | 2024-06-26 | — | — | EP | disclosed |
| CN-114286858-B | Folic acid producing strain, and preparation and application thereof | 赤峰制药股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| US-20230390346-A1 | PROBIOTIC BACILLUS COMPOSITIONS AND METHODS OF USE | BIOMEDIT, LLC | 2023-12-07 | — | — | US | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230272442-A1 | 5-METHYLFOLATE PRODUCING MICROORGANISM | CHIFENG PHARMACEUTICAL CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| EP-1414993-A2 | SCREENING-METHOD FOR INHIBITORS OF FOLATE-SYNTHESIS-PATHWAY ENZYMES | Aventis Pharma S.A. (FR) | 2004-05-06 | — | — | EP | disclosed |
| EP-1392816-A1 | PRODUCTION OF BIOAVAILABLE FOLIC ACID | Stichting Top-Instituut Voedselwetenschappen (NL) | 2004-03-03 | — | — | EP | disclosed |
| WO-2003104391-A2 | ANTIBACTERIAL TARGETS IN ALLOIOCOCCUS OTITIDIS | WYETH HOLDINGS CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |
| WO-2003012132-A2 | SCREENING METHOD FOR INHIBITORS OF FOLATE SYNTHESIS PATHWAY ENZYMES | AVENTIS PHARMA S.A. (FR) | 2003-02-13 | — | — | WO | disclosed |
| EP-1281769-A1 | Screening-method for inhibitors of folate-synthesis-pathway enzymes | Aventis Pharma S.A. (FR) | 2003-02-05 | — | — | EP | disclosed |
| WO-2002097063-A1 | PRODUCTION OF BIOAVAILABLE FOLIC ACID | CAMPINA B.V. (NL) | 2002-12-05 | — | — | WO | disclosed |
| EP-1262541-A1 | Production of bioavailable folic acid | Stichting Top-Instituut Voedselwetenschappen (NL) | 2002-12-04 | — | — | EP | disclosed |
| EP-0999284-A1 | Method for screening antimycotic substances using essential genes from c.albicans, and said genes | HOECHST MARION ROUSSEL (FR) | 2000-05-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | DHFR, DHPS, MTHFD1 | KDM4E 2117/4885MEN1 3295/4885RGS12 3316/4885 |
| US-20240390433-A1 | GENETICALLY MODIFIED BACILLUS SUBTILIS STRAIN AND USE AS A LIVE DELIVERY AND PRODUCTION SYSTEM | BLVRB, GLB1, GUSB | KDM4E 4205/4885MEN1 2725/4885RGS12 973/4885 |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | DHFR, DHPS, MTHFD1 | KDM4E 2117/4885MEN1 3295/4885RGS12 3316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.