Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP7 | P55210 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | RGS12 | O14924 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 7/20 | 0.39 |
| ▸ | DHFR | P00374 | 5/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | PAH | P00439 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25433714 | 0.93 | CASP7 (0.49) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| Pyrophosphoric Acid SCHEMBL2935409 | 0.90 | KDM4E (0.49) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL9152033 | 0.82 | CASP7 (0.52) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL26500536 | 0.81 | CASP7 (0.51) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL26499414 | 0.81 | CASP7 (0.57) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL7077068 | 0.80 | CASP7 (0.58) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL26499707 | 0.78 | MAPT (0.54) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL7362054 | 0.76 | CASP7 (0.58) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL16564277 | 0.76 | CASP7 (0.62) | CASP7HSD17B10KDM4EMEN1RGS12 | |
| SCHEMBL3721701 | 0.76 | KDM4E (0.46) | CASP7HSD17B10KDM4EMEN1RGS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112707921-A | Synthesis of fluorescence label of enzyme inhibitor | 南京碳硅人工智能生物医药技术研究院有限公司 | 2021-04-27 | — | — | CN | claimed |
| EP-2084519-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | Los Alamos National Security, LLC (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008127291-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2008-10-23 | — | — | WO | claimed |
| US-20080220441-A1 | Advanced drug development and manufacturing | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-11 | — | — | US | claimed |
| US-20060088900-A1 | Method for determining inhibition activity of a compound on one of the enzymes of the folate synthesis pathway | AVENTIS PHARMA S.A. (FR) | 2006-04-27 | — | — | US | claimed |
| EP-1414993-A2 | SCREENING-METHOD FOR INHIBITORS OF FOLATE-SYNTHESIS-PATHWAY ENZYMES | Aventis Pharma S.A. (FR) | 2004-05-06 | — | — | EP | claimed |
| WO-2003012132-A2 | SCREENING METHOD FOR INHIBITORS OF FOLATE SYNTHESIS PATHWAY ENZYMES | AVENTIS PHARMA S.A. (FR) | 2003-02-13 | — | — | WO | claimed |
| EP-1281769-A1 | Screening-method for inhibitors of folate-synthesis-pathway enzymes | Aventis Pharma S.A. (FR) | 2003-02-05 | — | — | EP | claimed |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | WASHINGTON UNIVERISTY (US) | 2025-09-23 | — | — | US | disclosed |
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | WASHINGTON UNIVERSITY (US) | 2023-10-12 | — | — | US | disclosed |
| US-20230272442-A1 | 5-METHYLFOLATE PRODUCING MICROORGANISM | CHIFENG PHARMACEUTICAL CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| EP-3681504-B1 | METHODS OF DETECTION USING X-RAY FLUORESCENCE | ICAGEN INC (US) | 2023-08-23 | — | — | EP | disclosed |
| CN-116096881-A | Microorganism producing 5-methyl folate | 赤峰制药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| US-11618912-B2 | Microorganisms and methods for producing sialylated and n-acetylglucosamine-containing oligosaccharides | Glycosyn LLC (US) | 2023-04-04 | — | — | US | disclosed |
| WO-2000046405-A9 | METHODS FOR IDENTIFYING DRUG TARGETS BASED ON GENOMIC SEQUENCE DATA | PALSSON BERNHARD (US) | 2001-09-07 | — | — | WO | disclosed |
| EP-1112382-A2 | ESSENTIAL GENES FROM C. ALBICANS AND A METHOD FOR SCREENING ANTIMYCOTIC SUBSTANCES USING SAID GENES | Aventis Pharma S.A. (FR) | 2001-07-04 | — | — | EP | disclosed |
| EP-1059354-A2 | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby | Ceres Incorporated (US) | 2000-12-13 | — | — | EP | disclosed |
| EP-1033405-A2 | Sequence-determined DNA fragments and corresponding polypeptides encoded thereby | Ceres Incorporated (US) | 2000-09-06 | — | — | EP | disclosed |
| EP-0999284-A1 | Method for screening antimycotic substances using essential genes from c.albicans, and said genes | HOECHST MARION ROUSSEL (FR) | 2000-05-10 | — | — | EP | disclosed |
| WO-2000015838-A2 | ESSENTIAL GENES FROM C. ALBICANS AND A METHOD FOR SCREENING ANTIMYCOTIC SUBSTANCES USING SAID GENES | AVENTIS PHARMA S.A. (FR) | 2000-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322667-A1 | DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME | DHFR, DHPS, MTHFD1 | CASP7 3180/4885HSD17B10 261/4885KDM4E 2117/4885 |
| US-12421187-B2 | Dihydrofolate synthase (DHFS) inhibiting agents and methods of making and using same | DHFR, DHPS, MTHFD1 | CASP7 3180/4885HSD17B10 261/4885KDM4E 2117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.