Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 5/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292759 | 0.82 | REN (0.38) | NR1H3NR1H2GPR119EPHX2REN | |
| SCHEMBL292325 | 0.81 | DRD2 (0.42) | NR1H3NR1H2REN | |
| SCHEMBL24700258 | 0.79 | NR1H2 (0.57) | NR1H3NR1H2GPR119 | |
| SCHEMBL3577862 | 0.73 | GPR119 (0.53) | GPR119EPHX2 | |
| SCHEMBL29709654 | 0.73 | NR1H2 (0.47) | NR1H3NR1H2GPR119 | |
| SCHEMBL24794733 | 0.73 | NR1H2 (0.47) | NR1H3NR1H2GPR119 | |
| SCHEMBL5726161 | 0.72 | MAPT (0.46) | NR1H3NR1H2GPR119 | |
| SCHEMBL31111837 | 0.72 | NR1H2 (0.46) | NR1H3NR1H2GPR119MGLL | |
| SCHEMBL23561131 | 0.72 | NR1H2 (0.42) | NR1H3NR1H2GPR119 | |
| SCHEMBL17385177 | 0.71 | NR1H2 (0.43) | NR1H3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158790-B2 | Cyclic amine compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-04-17 | — | — | US | disclosed |
| EP-2036896-B1 | CYCLIC AMINE COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2012-03-14 | — | — | EP | disclosed |
| US-20090286807-A1 | CYCLIC AMINE COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-11-19 | — | — | US | disclosed |
| EP-2036896-A1 | CYCLIC AMINE COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286807-A1 | CYCLIC AMINE COMPOUND | HRH3, HRH4, H1-0 | NR1H3 41/4885NR1H2 45/4885GPR119 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.