Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190937 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2GRK2RECQLCTDSP1TDP1 | |
| SCHEMBL7876952 | 0.85 | BRAF (0.45) | TSHRKMT2APTGS1PTGS2BRAF | |
| SCHEMBL20840389 | 0.82 | CYP3A4 (0.55) | SMN1; SMN2GRK2RECQLCTDSP1TDP1 | |
| SCHEMBL30566205 | 0.80 | PSIP1 (0.59) | SMN1; SMN2GRK2RECQLCTDSP1TDP1 | |
| SCHEMBL6221236 | 0.80 | PSIP1 (0.59) | SMN1; SMN2GRK2RECQLCTDSP1TDP1 | |
| SCHEMBL3988911 | 0.79 | ALOX15 (0.45) | SMN1; SMN2GRK2RECQLCTDSP1TDP1 | |
| SCHEMBL31568559 | 0.76 | CA2 (0.62) | SMN1; SMN2GRK2RECQLCTDSP1TDP1 | |
| SCHEMBL3019846 | 0.73 | CYP3A4 (0.49) | PTGS1PTGS2BRAFPSIP1CYP3A4 | |
| SCHEMBL1494488 | 0.73 | PTGS1 (0.45) | PTGS1PTGS2BRAFCA2PSIP1 | |
| SCHEMBL30526897 | 0.73 | KMT2A (0.56) | SMN1; SMN2GRK2RECQLCTDSP1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941919-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES | Genentech, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |