Penetratin

Penetratin

SCHEMBL29356568

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PTH1R Q03431 10/20 0.66
▸ KEAP1 Q14145 2/20 0.66
▸ IL23R Q5VWK5 5/20 0.62
▸ RXFP1 Q9HBX9 1/20 0.61
▸ GHSR Q92847 2/20 0.58
▸ NPY2R P49146 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Penetratin SCHEMBL29450548 0.97 KEAP1 (0.64) PTH1RKEAP1IL23RRXFP1GHSR
SCHEMBL31749000 0.97 PTH1R (0.63) PTH1RKEAP1IL23RRXFP1GHSR
SCHEMBL29710643 0.97 PTH1R (0.65) PTH1RKEAP1IL23RRXFP1GHSR
SCHEMBL29350300 0.97 PTH1R (0.64) PTH1RKEAP1IL23RRXFP1GHSR
SCHEMBL29429587 0.97 PTH1R (0.64) PTH1RKEAP1IL23RRXFP1GHSR
SCHEMBL30299196 0.95 PTH1R (0.67) PTH1RKEAP1IL23RRXFP1GHSR
Kqikiwfqnkkmkwkk-Nh2 SCHEMBL31748869 0.95 PTH1R (0.60) PTH1RKEAP1IL23RRXFP1GHSR
SCHEMBL30617122 0.94 PTH1R (0.61) PTH1RKEAP1IL23RGHSRNPY2R
SCHEMBL31232534 0.93 PTH1R (0.68) PTH1RKEAP1IL23RRXFP1
SCHEMBL30002139 0.93 PTH1R (0.63) PTH1RKEAP1IL23RRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4588 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747274-A2 PROTEIN-BASED DELIVERY SYSTEM Beth Israel Deaconess Medical Center, Inc. (US) 2026-05-27 — — EP claimed
CN-116493599-B Preparation method of silver nanocubes SOUTHEAST UNIVERSITY (CN) 2026-05-26 — — CN claimed
CN-122060054-A Nanometer antibody for resisting porcine delta coronavirus nucleocapsid protein, recombinant, preparation and application thereof 四川大学 2026-05-19 — — CN claimed
CN-122031717-A Efficient stable high-biocompatibility nano delivery carrier and preparation method and application thereof 广州墨羲科技有限公司 2026-05-15 — — CN claimed
WO-2026090590-A1 NANOPARTICLE FORMULATIONS FOR THE DELIVERY OF DNA TO ADIPOSE TISSUE Remedium Bio, Inc. (US) 2026-04-30 — — WO claimed
WO-2026090123-A1 METHODS AND COMPOSITIONS FOR MANAGING PESTS UOVO INTERNATIONAL LLC (US) 2026-04-30 — — WO claimed
US-20260108469-A1 COMPOSITIONS COMPRISING WATER INSOLUBLE DRUGS AND METHODS OF PRODUCING AND USING SAME NANO GHOST LTD (IL) 2026-04-23 — — US claimed
US-20260110698-A1 METHODS FOR QUANTIFYING FRATAXIN ACTIVITY LARIMAR THERAPEUTICS INC (US) 2026-04-23 — — US claimed
US-12590126-B2 Compounds for selective disruption of protein-protein interactions SYNTHEX, INC. (US) 2026-03-31 — — US claimed
US-20260085302-A1 COMPOSITIONS AND METHODS FOR CONTROLLING PLANT PESTS CONFLUENCE GENETICS, LLC (US) 2026-03-26 — — US claimed
CN-114316014-A Leader peptide for targeted inhibition of neuroblastoma cell growth, fusion peptide and application thereof 江苏医药职业学院 2022-04-12 — — CN claimed
CN-114269359-A Methods for making and using mesenchymal stem cell-derived secreted proteomes 康巴乔有限公司 2022-04-01 — — CN claimed
CN-114262698-A Leader peptide for targeted inhibition of MSI colorectal cancer cell growth, fusion peptide and application thereof 江苏医药职业学院 2022-04-01 — — CN claimed
US-20220090066-A1 CELL PENETRATING MOLECULE OXFORD UNIVERSITY INNOVATION LIMITED (GB) 2022-03-24 — — US claimed
EP-3600253-B1 LIPOSOMAL COMPOSITIONS AND SOLID ORAL DOSAGE FORMS COMPRISING THE SAME UNIV HEIDELBERG (DE) 2022-03-16 — — EP claimed
CN-114181315-A Endosome escape peptide and application thereof 清华大学 2022-03-15 — — CN claimed
EP-3955730-A1 EMBRYOGENESIS FACTORS FOR CELLULAR REPROGRAMMING OF A PLANT CELL Pioneer Hi-Bred International, Inc. (US) 2022-02-23 — — EP claimed
US-11253559-B2 Oncolytic viruses targeting STAT3 University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2022-02-22 — — US claimed
WO-2022032353-A1 RADIOPHARMACEUTICALS, USES THEREOF, AND METHODS FOR THE PRODUCTION THEREOF Clarity Pharmaceuticals Ltd (AU) 2022-02-17 — — WO claimed
CN-114007653-A Drug delivery vehicle and pharmaceutical preparation using the same 复旦大学 2022-02-01 — — CN claimed
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