Penetratin

Penetratin

SCHEMBL29450548

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O.O=C(O)C(F)(F)F

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 2/20 0.64
▸ PTH1R Q03431 10/20 0.64
▸ IL23R Q5VWK5 4/20 0.59
▸ RXFP1 Q9HBX9 1/20 0.59
▸ GHSR Q92847 2/20 0.56
▸ NPY2R P49146 1/20 0.56
▸ CCKBR P32239 1/20 0.55
▸ GLP1R P43220 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Penetratin SCHEMBL29356568 0.97 PTH1R (0.66) KEAP1PTH1RIL23RRXFP1GHSR
SCHEMBL31749000 0.95 PTH1R (0.63) KEAP1PTH1RIL23RRXFP1GHSR
SCHEMBL29710643 0.94 PTH1R (0.65) KEAP1PTH1RIL23RRXFP1GHSR
SCHEMBL29350300 0.94 PTH1R (0.64) KEAP1PTH1RIL23RRXFP1GHSR
SCHEMBL29429587 0.94 PTH1R (0.64) KEAP1PTH1RIL23RRXFP1GHSR
SCHEMBL30299196 0.93 PTH1R (0.67) KEAP1PTH1RIL23RRXFP1GHSR
Kqikiwfqnkkmkwkk-Nh2 SCHEMBL31748869 0.93 PTH1R (0.60) KEAP1PTH1RIL23RRXFP1GHSR
SCHEMBL30617122 0.91 PTH1R (0.61) KEAP1PTH1RIL23RGHSRNPY2R
SCHEMBL31232534 0.91 PTH1R (0.68) KEAP1PTH1RIL23RRXFP1CCKBR
SCHEMBL30002139 0.91 PTH1R (0.63) KEAP1PTH1RIL23RRXFP1CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 247 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122031716-A Carbon microsphere delivery carrier with controllable size in large range and preparation method and application thereof 广州墨羲科技有限公司 2026-05-15 — — CN claimed
US-20250228965-A1 NANOPARTICLES COMPRISING AT LEAST ONE METAL SALT AND AT LEAST ONE PEPTIDE CENTRE NAT RECH SCIENT (FR) 2025-07-17 — — US claimed
US-20250114464-A1 PRE-MRNA SLICE MODULATING PEPTIDE-CONJUGATED ANTISENSE THERAPEUTICS FOR THE TREATMENT OF DISEASES UNIV ALBERTA (CA) 2025-04-10 — — US claimed
US-20250092120-A1 ANTICANCER PEPTIDE AND USE IN TREATING CANCER A.T. STILL UNIVERSITY 2025-03-20 — — US claimed
US-20240254179-A1 Targeting Nuclear Speckles and DNA Speckle Association THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2024-08-01 — — US claimed
EP-4401710-A2 NANOPARTICLES COMPRISING AT LEAST ONE METAL SALT AND AT LEAST ONE PEPTIDE Centre National de la Recherche Scientifique CNRS (FR) 2024-07-24 — — EP claimed
CN-118304261-A Electric response nano-particle for epilepsy treatment or diagnosis and preparation method and application thereof 国家纳米科学中心 2024-07-09 — — CN claimed
WO-2024078534-A1 INTERFERING RNA FOR INHIBITING EXPRESSION OF MELANOPHILIN (MLPH) GENE, AND APPLICATION THEREOF 北京键凯科技股份有限公司 2024-04-18 — — WO claimed
WO-2024054991-A1 DIMERIC POLYPEPTIDE ANTAGONISTS OF THE NA/K-ATPASE-SRC RECEPTOR COMPLEX AND RELATED METHODS MARSHALL UNIVERSITY RESEARCH CORPORATION (US) 2024-03-14 — — WO claimed
WO-2023041639-A2 HYBRID NANOPARTICLES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2023-03-23 — — WO claimed
US-20260139254-A1 INTERFERING RNA FOR INHIBITING TOP1 GENE EXPRESSION AND USE THEREOF JENKEM TECH CO LTD BEIJING (CN) 2026-05-21 — — US disclosed
US-20260137791-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PD-L1 Bicyclerd Limited (GB) 2026-05-21 — — US disclosed
US-12630588-B2 Bicyclic peptide ligands specific for CD137 BICYCLETX LIMITED (GB) 2026-05-19 — — US disclosed
CN-122031716-A Carbon microsphere delivery carrier with controllable size in large range and preparation method and application thereof 广州墨羲科技有限公司 2026-05-15 — — CN disclosed
US-20260124312-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EPHA2 BICYCLETX LIMITED (GB) 2026-05-07 — — US disclosed
US-20220072140-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP Bicyclerd Limited (GB) 2022-03-10 — — US disclosed
WO-2022050419-A1 QUALITY IMPROVING AGENT FOR IPS CELLS, METHOD OF PRODUCING IPS CELLS, IPS CELLS, AND COMPOSITION FOR PRODUCING IPS CELLS Heartseed株式会社 2022-03-10 — — WO disclosed
CN-114144424-A Modified BCL9 mimetics 智慧疗法有限公司 2022-03-04 — — CN disclosed
US-20220064221-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR INTEGRIN ALPHA-V-BETA-3 BICYCLETX LIMITED (GB) 2022-03-03 — — US disclosed
EP-3955967-A1 PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR DELIVERY OF MOLECULES Aadigen, LLC (US) 2022-02-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630588-B2 Bicyclic peptide ligands specific for CD137 PTMS, IL36G, HLA-A KEAP1 4214/4885PTH1R 1663/4885IL23R 79/4885
US-20220064221-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR INTEGRIN ALPHA-V-BETA-3 ITGB3, ITGAV, ITGB1 KEAP1 3601/4885PTH1R 973/4885IL23R 691/4885
US-20220072140-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP MMEL1, MMP3, TIMP3 KEAP1 1245/4885PTH1R 2466/4885IL23R 878/4885
US-20260124312-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EPHA2 EPHA2, EPHB2, ERBB2 KEAP1 1704/4885PTH1R 1213/4885IL23R 1028/4885
US-20260137791-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR PD-L1 PDCD1LG2, CD274, PDCD1 KEAP1 1129/4885PTH1R 1368/4885IL23R 866/4885
US-20260139254-A1 INTERFERING RNA FOR INHIBITING TOP1 GENE EXPRESSION AND USE THEREOF TOP1, TOP2A, TOP2B KEAP1 1542/4885PTH1R 4757/4885IL23R 3731/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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