Sb-431542

Sb-431542

SCHEMBL29359059

NC(=O)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 17/20 1.00
CSNK1A1 P48729 2/20 1.00
CSNK1D P48730 2/20 1.00
CSNK1E P49674 2/20 1.00
ACVR1B P36896 2/20 1.00
KDM4E B2RXH2 1/20 1.00
RIPK2 O43353 1/20 1.00
PRKD3 O94806 1/20 1.00
ALDH1A1 P00352 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
MAPT P10636 1/20 1.00
HPGD P15428 1/20 1.00
MAPK1 P28482 1/20 1.00
CYP2C19 P33261 1/20 1.00
TGFBR2 P37173 1/20 1.00
RPS6KA1 Q15418 1/20 1.00
CSNK1A1L Q8N752 1/20 1.00
HSD17B10 Q99714 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sb-431542 SCHEMBL29381798 1.00 TGFBR1 (1.00) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
Sb-431542 SCHEMBL310028 1.00 TGFBR1 (1.00) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
Sb-431542 SCHEMBL29432843 0.99 TGFBR1 (0.98) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
Sb-431542 SCHEMBL2681356 0.99 TGFBR1 (0.98) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
SCHEMBL29362480 0.94 TGFBR1 (1.00) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
SCHEMBL373737 0.94 TGFBR1 (1.00) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
Sb-431542 SCHEMBL155156 0.92 TGFBR1 (0.85) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
Sb-431542 SCHEMBL29353092 0.92 TGFBR1 (0.85) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
Sb-431542 SCHEMBL30033986 0.92 TGFBR1 (0.85) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B
Sb-431542 SCHEMBL21046666 0.91 TGFBR1 (0.84) TGFBR1CSNK1A1CSNK1DCSNK1EACVR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12065671-B2 Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2024-08-20 US claimed
EP-4347795-A1 METHODS TO GENERATE MACULAR, CENTRAL AND PERIPHERAL RETINAL PIGMENT EPITHELIAL CELLS The United States of America, as represented by The Secretary, Department of Health and Human Services (US) 2024-04-10 EP claimed
EP-4345160-A2 METHOD FOR REPRODUCIBLE DIFFERENTIATION OF CLINICAL-GRADE RETINAL PIGMENT EPITHELIUM CELLS The United States of America, as represented by The Secretary, Department of Health and Human Services (US) 2024-04-03 EP claimed
EP-3347456-B1 METHOD FOR REPRODUCIBLE DIFFERENTIATION OF CLINICAL-GRADE RETINAL PIGMENT EPITHELIUM CELLS US HEALTH (US) 2023-12-27 EP claimed
WO-2022251499-A1 METHODS TO GENERATE MACULAR, CENTRAL AND PERIPHERAL RETINAL PIGMENT EPITHELIAL CELLS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-12-01 WO claimed
WO-2022178986-A1 METHOD AND DRUG FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO MESODERM LINEAGE OR TROPHOBLAST LINEAGE 澳门大学 2022-09-01 WO claimed
WO-2022093967-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS CHARACTERIZED WITH TGF-BETA ACTIVITY THE JOHNS HOPKINS UNIVERSITY (US) 2022-05-05 WO claimed
EP-4680255-A1 METHODS FOR PRODUCING STABLE HUMAN CHONDROCTYES AND THEIR USE FOR PROMOTING CARTILLAGE GROWTH AND REPAIR The United States of America, as represented by the Secretary, Department of Health and Human Services (US) 2026-01-21 EP disclosed
EP-4346928-B1 BIODEGRADABLE TISSUE SCAFFOLD WITH SECONDARY MATRIX TO HOST WEAKLY ADHERENT CELLS US HEALTH (US) 2026-01-14 EP disclosed
US-20250290038-A1 METHOD FOR CONVERTING HUMAN SOMATIC CELLS INTO PROLIFERATIVE NEURAL STEM CELLS KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2025-09-18 US disclosed
US-12404489-B2 Establishing topographic organization in three-dimensional tissue culture MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2025-09-02 US disclosed
EP-3565887-B1 METHODS FOR GENERATING SKELETAL MUSCLE PROGENITOR CELLS UNIV CALIFORNIA (US) 2025-07-16 EP disclosed
US-20250136948-A1 INDUCTION OF PLURIPOTENT CELLS THE SCRIPPS RESEARCH INSTITUTE 2025-05-01 US disclosed
CN-114641571-A Treatment and prevention of WWP2 mediated diseases 新加坡国立大学 2022-06-17 CN disclosed
WO-2022112809-A1 EFFICIENT AND RAPID SPECIFICATION OF SPINAL NEURONAL SUBTYPES FROM HUMAN PLURIPOTENT STEM CELLS INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2022-06-02 WO disclosed
EP-4001402-A1 MACS-BASED PURIFICATION OF STEM CELL-DERIVED RETINAL PIGMENT EPITHELIUM FUJIFILM Cellular Dynamics, Inc. (US) 2022-05-25 EP disclosed
WO-2022093967-A1 COMPOSITIONS AND METHODS FOR TREATING DISORDERS CHARACTERIZED WITH TGF-BETA ACTIVITY THE JOHNS HOPKINS UNIVERSITY (US) 2022-05-05 WO disclosed
EP-3983544-A1 TREATMENT AND PREVENTION OF DISEASE MEDIATED BY WWP2 National University of Singapore (SG) 2022-04-20 EP disclosed
EP-3966315-A1 METHODS FOR THE PRODUCTION OF HEPATOCYTES FUJIFILM Cellular Dynamics, Inc. (US) 2022-03-16 EP disclosed
WO-2022019768-A1 CLOSED MANUFACTURING PROCESSES FOR LARGE SCALE MANUFACTURING OF PLURIPOTENT STEM CELL DERIVED CELLS NCARDIA B.V. (NL) 2022-01-27 WO disclosed