Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22488585 | 0.82 | SPR (0.47) | SPRRXFP1SMN1; SMN2 | |
| SCHEMBL29359207 | 0.82 | SPR (0.47) | SPRRXFP1SMN1; SMN2 | |
| SCHEMBL20899871 | 0.80 | SPR (0.34) | SPRRXFP1RIPK1SMN1; SMN2 | |
| SCHEMBL28408901 | 0.80 | RIPK1 (0.35) | SPRRXFP1RIPK1SMN1; SMN2 | |
| SCHEMBL18312206 | 0.79 | SPR (0.41) | SPRRXFP1 | |
| SCHEMBL28692543 | 0.79 | RXFP1 (0.49) | RXFP1SMN1; SMN2 | |
| SCHEMBL19014078 | 0.78 | CHRNB2 (0.46) | SPRRXFP1RIPK1SMN1; SMN2 | |
| SCHEMBL15298469 | 0.75 | ATM (0.38) | SMN1; SMN2 | |
| SCHEMBL20221868 | 0.75 | TACR1 (0.33) | SPRRXFP1RIPK1SMN1; SMN2 | |
| SCHEMBL26644049 | 0.74 | DPP4 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099882-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |