Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 3/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369460 | 0.88 | ALDH1A1 (0.53) | ALDH1A1HPGDELANEF2PLAU | |
| SCHEMBL29368289 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HPGDELANEF2PLAU | |
| SCHEMBL29368322 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HPGDELANEF2PLAU | |
| SCHEMBL22559668 | 0.83 | ALDH1A1 (0.49) | ALDH1A1HPGDELANEF2PLAU | |
| SCHEMBL29365841 | 0.82 | ALDH1A1 (0.48) | ALDH1A1HPGDELANEF2PLAU | |
| SCHEMBL29218170 | 0.80 | FGFR1 (0.53) | HPGDMAPTKDM4EMEN1GFER | |
| SCHEMBL24543271 | 0.75 | MAPT (0.55) | ALDH1A1HPGDTSHRACHEMAPT | |
| SCHEMBL22559669 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDTSHRACHEMAPT | |
| SCHEMBL29368311 | 0.75 | MAPT (0.55) | ALDH1A1HPGDTSHRACHEMAPT | |
| SCHEMBL19586107 | 0.74 | L3MBTL1 (0.51) | ALDH1A1TSHRACHEMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3955914-A1 | NOVEL COMPOUNDS AND METHODS OF USE TREATING FRUCTOSE-RELATED DISORDERS OR DISEASES | Colorado Research Partners, LLC (US) | 2022-02-23 | — | — | EP | disclosed |
| CN-114007602-A | Novel compounds and methods of use for treating fructose-related disorders or diseases | 科罗拉多研究合作伙伴有限责任公司 | 2022-02-01 | — | — | CN | disclosed |