Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | HPN | P05981 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30163022 | 0.84 | NPC1 (0.42) | FGFR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24933448 | 0.84 | SMN1; SMN2 (0.59) | FGFR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30999883 | 0.81 | FGFR1 (0.50) | FGFR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29366393 | 0.80 | ALDH1A1 (0.51) | FGFR1ABHD16AMAPTHPGDGFER | |
| SCHEMBL30163006 | 0.79 | GABRP (0.36) | FGFR1IDO1TDO2NPC1RAB9A | |
| SCHEMBL2677079 | 0.76 | PDE5A (0.44) | KMT2AKDM4E | |
| SCHEMBL14693420 | 0.75 | MAPT (0.46) | FGFR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4721544 | 0.73 | NPSR1 (0.59) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL14693601 | 0.73 | RAB9A (0.45) | FGFR1ABHD16ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9022581 | 0.72 | ABHD16A (0.54) | PDE4APDE4BPDE4CPDE4DABHD16A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |