SCHEMBL29368348

SCHEMBL29368348

C[C@H](N)Cn1ccc2cc(F)c(Cl)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 19/20 1.00
HTR2A P28223 17/20 1.00
HTR2B P41595 3/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2C9 P11712 1/20 1.00
HDAC1 Q13547 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8959606 1.00 HTR2C (1.00) HTR2CHTR2AHTR2BCYP1A2CYP3A4
SCHEMBL255454 1.00 HTR2C (1.00) HTR2CHTR2AHTR2BCYP1A2CYP3A4
SCHEMBL8959930 1.00 HTR2C (1.00) HTR2CHTR2AHTR2BCYP1A2CYP3A4
SCHEMBL9232946 0.94 HTR2C (1.00) HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959707 0.89 HTR2C (0.79) HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959674 0.89 HTR2C (0.79) HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959555 0.89 HTR2C (0.79) HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959718 0.89 HTR2C (0.79) HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959565 0.89 HTR2C (0.79) HTR2CHTR2AHTR2BCYP1A2CYP3A4
Fumaric Acid SCHEMBL8959682 0.89 HTR2C (0.79) HTR2CHTR2AHTR2BCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107229-A1 REDUCING THE ADDICTIVE LIABILITY OF OPIOID ANALGESICS BY CO- ADMINISTERING 5HT2 RECEPTOR AGONISTS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2026-05-21 WO disclosed
EP-4395772-A1 METHODS OF PREVENTING AND TREATING PAIN AND ASSOCIATED SYMPTOMS Ethismos Research, Inc. (US) 2024-07-10 EP disclosed
CN-118176001-A Methods for preventing and treating pain and related symptoms 埃塞斯莫斯研究股份有限公司 2024-06-11 CN disclosed
US-20230085440-A1 METHODS OF PREVENTING AND TREATING PAIN AND ASSOCIATED SYMPTOMS ETHISMOS RESEARCH, INC. (US) 2023-03-16 US disclosed
WO-2023034293-A1 METHODS OF PREVENTING AND TREATING PAIN AND ASSOCIATED SYMPTOMS ETHISMOS RESEARCH, INC. (US) 2023-03-09 WO disclosed
US-20230035892-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER FLAGSHIP PIONEERING, INC. 2023-02-02 US disclosed
US-20220249440-A1 MUSCLE REGENERATION PROMOTER SATO PHARMACEUTICAL CO., LTD. (JP) 2022-08-11 US disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220226508-A1 METHODS AND COMPOSITIONS FOR TREATING EPILEPSY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-07-21 US disclosed
EP-3976187-A1 METHODS AND COMPOSITIONS FOR TREATING EPILEPSY The Regents of the University of California (US) 2022-04-06 EP disclosed
US-11274158-B2 Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2022-03-15 US disclosed
CN-114007692-A Methods and compositions for treating epilepsy 加利福尼亚大学董事会 2022-02-01 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220226508-A1 METHODS AND COMPOSITIONS FOR TREATING EPILEPSY HTR2B, HTR3B, HTR1B HTR2C 9/4885HTR2A 4/4885HTR2B 1/4885
US-20220249440-A1 MUSCLE REGENERATION PROMOTER MUSK, MYLK2, MYH2 HTR2C 72/4885HTR2A 28/4885HTR2B 4/4885
US-20230085440-A1 METHODS OF PREVENTING AND TREATING PAIN AND ASSOCIATED SYMPTOMS KCNN3, KCNN2, KCNN1 HTR2C 509/4885HTR2A 339/4885HTR2B 486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.