Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377043 | 0.83 | ACP1 (0.56) | ACP1RIPK2 | |
| SCHEMBL29368456 | 0.83 | ACP1 (0.56) | ACP1RIPK2 | |
| SCHEMBL18377063 | 0.83 | TTK (0.51) | RIPK2CDK1TTKBMPR2JUN | |
| SCHEMBL29368477 | 0.83 | TTK (0.51) | RIPK2CDK1TTKBMPR2JUN | |
| SCHEMBL29205093 | 0.83 | EGFR (0.44) | ACP1RIPK2TP53SYKFGFR2 | |
| SCHEMBL29371147 | 0.80 | SRC (0.53) | RIPK2USP2CYP1A2LMNAMAPK1 | |
| SCHEMBL18376821 | 0.80 | SRC (0.53) | RIPK2USP2CYP1A2LMNAMAPK1 | |
| SCHEMBL18376603 | 0.79 | FGFR2 (0.51) | RIPK2KDRFGFR2TTK | |
| SCHEMBL29370825 | 0.79 | FGFR2 (0.51) | RIPK2KDRFGFR2TTK | |
| SCHEMBL18376788 | 0.79 | FGFR2 (0.58) | RIPK2KDRFGFR2TTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |