Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Capsaicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 known ✓ | Q8NER1 | 9/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KDM1A | O60341 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zucapsaicin SCHEMBL41210 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Zucapsaicin SCHEMBL29787104 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL8085 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL8086 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL4302468 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL10956845 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6065297 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6905200 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL29473408 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL16309566 | 0.99 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 498 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025229086-A1 | ADHESIVE COSMETIC COMPOUNDS AND USES THEREOF | SKINOSIVE (FR) | 2025-11-06 | — | — | WO | claimed |
| CN-120053306-A | Zanthoxylum bungeanum extract microcapsule and preparation method and application thereof | 成都极萃新材料有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-119909088-A | Pharmaceutical composition for treating or preventing gallbladder cancer | 武汉科技大学 | 2025-05-02 | — | — | CN | claimed |
| CN-115627629-B | Antifouling processing method for fishing net rope by utilizing hydroxyl acid ester oligomer compound antifouling agent and product thereof | 南京源健生物科技有限公司 | 2025-04-04 | — | — | CN | claimed |
| CN-115427421-B | 3' -Ketoglycoside compounds for slow release of volatile alcohols | 格莱克科学有限公司 | 2025-04-01 | — | — | CN | claimed |
| CN-119708124-A | Liquid phase synthesis method of bursin tripeptide | 厦门胜泽泰医药科技有限公司 | 2025-03-28 | — | — | CN | claimed |
| US-20250099421-A1 | Analgesic Therapeutics Based on conjugation of Biocompatible Polymers to Ion Channel Modulators | Relevium Medical (IE) | 2025-03-27 | — | — | US | claimed |
| CN-119462827-A | Semi-continuous liquid phase synthesis method of bursin tripeptide | 漳州胜泽泰医药科技有限公司 | 2025-02-18 | — | — | CN | claimed |
| US-20240424024-A1 | PHARMACEUTICAL COMPOSITION AND KIT COMPRISING AN IMMUNOMODULATORY SUBSTANCE FOR TREATING DISEASES | ELLENNBE GMBH (DE) | 2024-12-26 | — | — | US | claimed |
| CN-119095955-A | Liquid enzyme preparation | 天野酶制品株式会社 | 2024-12-06 | — | — | CN | claimed |
| WO-2022182523-A1 | COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES | Natural Extraction Systems, LLC (US) | 2022-09-01 | — | — | WO | claimed |
| CN-114958134-A | Water-based epoxy moisture-curing acid-and-alkali-resistant coating and preparation method thereof | 石家庄市鱼莎电力物资工程有限公司 | 2022-08-30 | — | — | CN | claimed |
| CN-114942500-A | Rat-proof belt for optical cable and preparation method thereof | 长飞光纤光缆股份有限公司 | 2022-08-26 | — | — | CN | claimed |
| CN-114917190-A | Product for masking bitter taste | 郑州味千生物技术有限公司 | 2022-08-19 | — | — | CN | claimed |
| EP-3380526-B1 | ENVIRONMENTALLY FRIENDLY PROCESS FOR THE PREPARATION OF NANOCELLULOSE AND DERIVATIVES THEREOF | ORGANOFUEL SWEDEN AB (SE) | 2022-07-27 | — | — | EP | claimed |
| CN-114687241-A | Preparation method of antibacterial packaging paper, and product and application thereof | 江苏省农业科学院 | 2022-07-01 | — | — | CN | claimed |
| CN-110627644-B | Capsinoid compound, pharmaceutically acceptable salt thereof, and preparation method and application thereof | 株洲千金药业股份有限公司 | 2022-06-07 | — | — | CN | claimed |
| EP-3990597-A2 | IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS | Givaudan SA (CH) | 2022-05-04 | — | — | EP | claimed |
| CN-114306609-A | Calcium overload type micromolecular drug self-assembly nanoparticles and application thereof | 中国药科大学 | 2022-04-12 | — | — | CN | claimed |
| CN-114052234-A | Yak oil hotpot condiment | 若尔盖县唐克吐蕃高原生态牧业农民专业合作社 | 2022-02-18 | — | — | CN | claimed |