Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Capsaicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 known ✓ | Q8NER1 | 9/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KDM1A | O60341 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zucapsaicin SCHEMBL41210 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Zucapsaicin SCHEMBL29787104 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL8085 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL29370401 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL4302468 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL10956845 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6065297 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6905200 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL29473408 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL16309566 | 0.99 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 62435 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144725-A1 | TOOTH DESENSITIZING ORAL CARE COMPOSITIONS, DEVICES, AND METHODS | THE PROCTER & GAMBLE COMPANY (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144780-A1 | COMPOSITION FOR ENHANCING ADRENOMEDULLIN GENE EXPRESSION | HOUSE WELLNESS FOODS CORPORATION (JP) | 2026-05-28 | — | — | US | claimed |
| EP-4210687-B1 | TRPV1 AGONISTS IN THE PREVENTION OF DIABETIC ULCERS | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2026-05-27 | — | — | EP | claimed |
| CN-118436621-B | Capsaicin electrode slice | NANJING DING SHI MEDICAL DEVICES Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-120988584-B | Capsaicin/sodium alginate-polyacrylamide hydrogel modified PDMS (polydimethylsiloxane) anti-fouling coating, and preparation method and application thereof | Yangtze River Delta Ship and Marine Equipment Technology Innovation Center (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-224287200-U | Multi-scene self-adaptive armored optical cable | JIANGSU TUYUE ELECTRONIC TECHNOLOGY Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122078003-A | Underwater curing anti-corrosion anti-biological coating and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075527-A | A guinea pig model for chronic bronchitis type chronic obstructive pulmonary disease, and its preparation method and application | — | 2026-05-26 | — | — | CN | claimed |
| CN-122082257-A | Material for ultra-high molecular weight polyethylene protective net and preparation process thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094572-A | Novel feed additive composition | — | 2026-05-26 | — | — | CN | claimed |
| US-4546112-A | APPLYING CAPSAICIN OR ITS SALTS | THE PROCTER & GAMBLE COMPANY (US) | 1985-10-08 | — | — | US | claimed |
| US-4536404-A | Method and composition for treating post-herpetic neuralgia | DERMATOLOGICAL ENTERPRISES, LTD. (US) | 1985-08-20 | — | — | US | claimed |
| EP-0045280-B1 | COMPOSITION FOR THE CONTROL OF SLUGS AND SNAILS, CONTAINER FOR THIS COMPOSITION AND USE OF SUBSTANCES IN PESTICIDES FOR SLUGS AND SNAILS | SIPURO AG (CH) | 1985-04-03 | — | — | EP | claimed |
| US-4486450-A | Method of treating psoriatic skin and composition | DERMALOGICAL ENTERPRISES, LTD. (US) | 1984-12-04 | — | — | US | claimed |
| US-4455146-A | THERMOPLASTIC ELASTOMERS, OILS OR FATTY ACID, TACKFIER, AND A MEDICINE | HISAMITSU PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | claimed |
| EP-0095512-A1 | Antipsoriatic composition | Bernstein, Joel E. (US) | 1983-12-07 | — | — | EP | claimed |
| US-4400398-A | SOLVENT EXTRACTION UNDER CRITICAL TEMPERATURE AND PRESSURE CONDITIONS | FRIED. KRUPP GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-08-23 | — | — | US | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| US-4313958-A | ADMINISTERING CAPSATICIN | THE PROCTER & GAMBLE COMPANY (US) | 1982-02-02 | — | — | US | claimed |
| US-4097607-A | Deterrent composition, method of using same, and article coated thereby | LARSON KENNETH A | 1978-06-27 | — | — | US | claimed |