Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zucapsaicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 known ✓ | Q8NER1 | 9/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KDM1A | O60341 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zucapsaicin SCHEMBL41210 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL8085 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL8086 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL29370401 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL4302468 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL10956845 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6065297 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6905200 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL29473408 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL16309566 | 0.99 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099421-A1 | Analgesic Therapeutics Based on conjugation of Biocompatible Polymers to Ion Channel Modulators | Relevium Medical (IE) | 2025-03-27 | — | — | US | claimed |
| CN-113150716-B | Water-based coating heat-sealing adhesive, coating process and application of water-based coating heat-sealing adhesive in medical dialyzing paper | 浙江华邦特种纸业有限公司 | 2022-08-12 | — | — | CN | claimed |
| US-20250144067-A1 | PERSONALIZED STARVATION THERAPY FOR CANCER | FAETH THERAPEUTICS, INC. | 2025-05-08 | — | — | US | disclosed |
| WO-2025068983-A1 | ANALGESIC THERAPEUTICS BASED ON CONJUGATION OF BIOCOMPATIBLE POLYMERS TO ION CHANNEL MODULATORS | Relevium Medical (IE) | 2025-04-03 | — | — | WO | disclosed |
| US-20250099421-A1 | Analgesic Therapeutics Based on conjugation of Biocompatible Polymers to Ion Channel Modulators | Relevium Medical (IE) | 2025-03-27 | — | — | US | disclosed |
| US-20250099598-A1 | Analgesic Therapeutics Based on Conjugation of Biocompatible Polymers to Ion Channel Modulators | Relevium Medical (IE) | 2025-03-27 | — | — | US | disclosed |
| CN-117770450-B | High-purity capsaicin composition, and preparation method and application thereof | 天津福来特新材料科技有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-117770450-A | High-purity capsaicin composition, and preparation method and application thereof | 天津福来特新材料科技有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-113150716-B | Water-based coating heat-sealing adhesive, coating process and application of water-based coating heat-sealing adhesive in medical dialyzing paper | 浙江华邦特种纸业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-113150716-B | Water-based coating heat-sealing adhesive, coating process and application of water-based coating heat-sealing adhesive in medical dialyzing paper | 浙江华邦特种纸业有限公司 | 2022-08-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250099598-A1 | Analgesic Therapeutics Based on Conjugation of Biocompatible Polymers to Ion Channel Modulators | TRPV1, TRPV4, TRPV3 | TRPV1 1/4885CYP1A2 4172/4885CYP3A4 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.