Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zucapsaicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 known ✓ | Q8NER1 | 9/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KDM1A | O60341 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zucapsaicin SCHEMBL29787104 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL8085 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL8086 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL29370401 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL4302468 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL10956845 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6065297 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL6905200 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| Capsaicin SCHEMBL29473408 | 1.00 | TRPV1 (1.00) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL16309566 | 0.99 | TRPV1 (0.98) | TRPV1CYP1A2CYP3A4ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2671 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4701663-A1 | PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS, COMBINATIONS AND USES THEREOF | Insilico Medicine IP Limited (HK) | 2026-03-04 | — | — | EP | claimed |
| EP-4680210-A1 | MEDICAL PATCH COMPRISING SKIN IRRITATING ACTIVE AGENT | LTS Lohmann Therapie-Systeme AG (DE) | 2026-01-21 | — | — | EP | claimed |
| WO-2024222890-A1 | PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS, COMBINATIONS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2024-10-31 | — | — | WO | claimed |
| US-12109268-B2 | Nanoparticle delivery system for targeted anti-obesity treatment | UNIVERSITY OF WYOMING (US) | 2024-10-08 | — | — | US | claimed |
| WO-2024189213-A1 | MEDICAL PATCH COMPRISING SKIN IRRITATING ACTIVE AGENT | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2024-09-19 | — | — | WO | claimed |
| CN-117770450-B | High-purity capsaicin composition, and preparation method and application thereof | 天津福来特新材料科技有限公司 | 2024-06-21 | — | — | CN | claimed |
| CN-118225955-A | High performance liquid chromatography for efficiently separating and detecting capsaicin composition related substances | 赤峰福来特化工有限公司 | 2024-06-21 | — | — | CN | claimed |
| US-20240197867-A1 | NEURAL CONTROL OF ADAPTIVE IMMUNITY | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2024-06-20 | — | — | US | claimed |
| CN-117770450-A | High-purity capsaicin composition, and preparation method and application thereof | 天津福来特新材料科技有限公司 | 2024-03-29 | — | — | CN | claimed |
| US-11904047-B1 | Formulation and delivery systems for herbal compositions for the treatment of canker sores (recurrent aphthous stomatitis) and related conditions | TRAN SANDIE (US) | 2024-02-20 | — | — | US | claimed |
| US-20020044976-A1 | Microparticles | PACIRA PHARMACEUTICALS, INC. | 2002-04-18 | — | — | US | claimed |
| WO-2002028370-A1 | BIODEGRADABLE MICROPARTICLES FOR CONTROLLED RELEASE ADMINISTRATION, WITH PURIFIED AMYLOPECTIN-BASED STARCH OF REDUCED MOLECULAR WEIGHT | JAGOTEC AG (CH) | 2002-04-11 | — | — | WO | claimed |
| WO-2002028375-A1 | A CONTROLLED-RELEASE, PARENTERALLY ADMINISTRABLE MICROPARTICLE PREPARATION | JAGOTEC AG (CH) | 2002-04-11 | — | — | WO | claimed |
| US-5762963-A | DISPERSING IN SOLID OR GEL VEHICLE IN WHICH CONCENTRATION OF CAPSAICINOID DECREASES FROM CENTER TOWARD PERIPHERY; FOR MOUTH, THROAT PAIN RELIEF | EMORY UNIVERSITY (US) | 1998-06-09 | — | — | US | claimed |
| WO-1996040079-A1 | METHOD AND COMPOSITIONS FOR CONTROLLING ORAL AND PHARYNGEAL PAIN USING CAPSAICINOIDS | EMORY UNIVERSITY (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0506658-B1 | COMPOSITIONS AND METHOD FOR TREATING PAINFUL, INFLAMMATORY OR ALLERGIC DISORDERS | CISCO LP (US) | 1996-05-29 | — | — | EP | claimed |
| EP-0506658-A4 | COMPOSITIONS AND METHOD FOR TREATING PAINFUL, INFLAMMATORY OR ALLERGIC DISORDERS | — | 1993-03-03 | — | — | EP | claimed |
| EP-0506658-A1 | COMPOSITIONS AND METHOD FOR TREATING PAINFUL, INFLAMMATORY OR ALLERGIC DISORDERS. | CISCO LP (US) | 1992-10-07 | — | — | EP | claimed |
| US-5063060-A | COMPOSITIONS AND METHOD FOR TREATING PAINFUL, INFLAMMATORY OR ALLERGIC DISORDERS | CISCO LIMITED PARTNERSHIP (US) | 1991-11-05 | — | — | US | claimed |
| WO-1991008738-A1 | COMPOSITIONS AND METHOD FOR TREATING PAINFUL, INFLAMMATORY OR ALLERGIC DISORDERS | CISCO LIMITED PARTNERSHIP (US) | 1991-06-27 | — | — | WO | claimed |