SCHEMBL29370768

SCHEMBL29370768

NC(C(=O)O)c1cc(O)ccc1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 1.00
KMT2A Q03164 4/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 1/20 1.00
ESR1 P03372 2/20 0.48
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
HSD17B10 Q99714 5/20 0.43
GRM1 Q13255 7/20 0.41
TDP1 Q9NUW8 4/20 0.41
KMO O15229 1/20 0.39
KDM4E B2RXH2 4/20 0.39
ALDH1A1 P00352 4/20 0.39
HPGD P15428 4/20 0.39
GRM2 Q14416 2/20 0.39
CYP2C9 P11712 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12648575 1.00 MEN1 (1.00) MEN1KMT2ACYP1A2CYP3A4ESR1
SCHEMBL30938556 1.00 MEN1 (1.00) MEN1KMT2ACYP1A2CYP3A4ESR1
SCHEMBL29367546 0.82 MEN1 (0.70) MEN1KMT2ACYP1A2CYP3A4ESR1
SCHEMBL25362682 0.81 MEN1 (0.68) MEN1KMT2ACYP1A2CYP3A4CA12
SCHEMBL8615977 0.81 MEN1 (0.68) MEN1KMT2ACYP1A2CYP3A4CA12
SCHEMBL9004077 0.78 MEN1 (0.64) MEN1KMT2ACYP1A2CYP3A4HSD17B10
SCHEMBL9004079 0.78 MEN1 (0.64) MEN1KMT2ACYP1A2CYP3A4HSD17B10
SCHEMBL10596148 0.77 MEN1 (0.62) MEN1KMT2ACYP1A2CYP3A4ESR1
SCHEMBL11018237 0.77 MEN1 (0.62) MEN1KMT2ACYP1A2CYP3A4ESR1
SCHEMBL1159922 0.75 MEN1 (0.59) MEN1KMT2ACYP1A2CYP3A4GRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120049510-A Coordinated operation optimization method and system for multi-type pumping and storage units 国家电网有限公司华中分部 2025-05-27 CN claimed
US-20250129045-A1 SMALL MOLECULE PIM AND MTOR KINASE INHIBITOR AND METHODS OF USE THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2025-04-24 US claimed
US-12156879-B2 Combining BACE1 inhibitors with mGluR agonists for Alzheimer's disease therapy UNIVERSITY OF CONNECTICUT (US) 2024-12-03 US claimed
WO-2024063818-A9 METHODS AND COMPOSITIONS FOR GENERATING OLIGODENDROCYTE PROGENITOR CELLS TRAILHEAD BIOSYSTEMS INC. (US) 2024-05-23 WO claimed
WO-2023150534-A1 SMALL MOLECULE PIM AND MTOR KINASE INHIBITOR AND METHODS OF USE THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2023-08-10 WO claimed
CN-115906456-A Hydrogen-containing energy IES scheduling optimization model considering response uncertainty of demand side 国网甘肃省电力公司武威供电公司 2023-04-04 CN claimed
CN-106849176-B Modeling method of random sequence optimization model considering wind power uncertainty 国网江苏省电力公司南京供电公司 2023-02-17 CN claimed
US-20260137689-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS ALTO NEUROSCIENCE INC (US) 2026-05-21 US disclosed
CN-120617206-B Ergosterol-loaded engineering exosome dual-drug-loading system and preparation method and application thereof 无锡市第二人民医院 2026-05-15 CN disclosed
CN-120617206-B Ergosterol-loaded engineering exosome dual-drug-loading system and preparation method and application thereof 无锡市第二人民医院 2026-05-15 CN disclosed
US-20260036593-A1 DEFECTIVE CALCIUM SIGNALING AS A TOOL IN AUTISM SPECTRUM DISORDERS UNIV CALIFORNIA (US) 2026-02-05 US disclosed
CN-121177271-A Application of mGluR5 agonist CHPG in preparation of antithrombotic drugs 贵州医科大学 2025-12-23 CN disclosed
CN-121177271-A Application of mGluR5 agonist CHPG in preparation of antithrombotic drugs 贵州医科大学 2025-12-23 CN disclosed
US-20230035892-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER FLAGSHIP PIONEERING, INC. 2023-02-02 US disclosed
CN-115379847-A Synthetic peptides for modulating metabotropic glutamate receptor 5 拉托科公司 2022-11-22 CN disclosed
WO-2022159629-A1 COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION- RELATED DYSFUNCTION EXISTS ALTO NEUROSCIENCE, INC. (US) 2022-07-28 WO disclosed
US-20220226331-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS ALTO NEUROSCIENCE, INC. 2022-07-21 US disclosed
US-11274158-B2 Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) 2022-03-15 US disclosed
US-20220056009-A1 4-(3-CYANOPHENYL)-6-PYRIDINYLPYRIMIDINE MGLU5 MODULATORS NXERA PHARMA UK LIMITED (GB) 2022-02-24 US disclosed
US-20220031778-A1 METHOD OF REDUCING NEURONAL MICROTUBULE BINDING PROTEIN TAU (TAU) LEVELS INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) 2022-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12156879-B2 Combining BACE1 inhibitors with mGluR agonists for Alzheimer's disease therapy BACE1, PSEN1, PSEN2 MEN1 3300/4885KMT2A 2096/4885CYP1A2 4795/4885
US-20260137689-A1 INTEGRATION OF MOLECULAR MECHANISMS IN THE STRIATUM AS A COMBINATION DRUG STRATEGY FOR THE TREATMENT OF PSYCHIATRIC AND NEUROLOGICAL DISORDERS IN WHICH ANHEDONIA OR MOTIVATION-RELATED DYSFUNCTION EXISTS CHRNA5, CHRNA2, CHRNA4 MEN1 4793/4885KMT2A 1265/4885CYP1A2 2512/4885
US-20260036593-A1 DEFECTIVE CALCIUM SIGNALING AS A TOOL IN AUTISM SPECTRUM DISORDERS CASR, ORAI1, TRPC3 MEN1 3878/4885KMT2A 4664/4885CYP1A2 3673/4885
US-20250129045-A1 SMALL MOLECULE PIM AND MTOR KINASE INHIBITOR AND METHODS OF USE THEREOF PIM3, PIM1, PIM2 MEN1 3315/4885KMT2A 2281/4885CYP1A2 4861/4885
US-20220056009-A1 4-(3-CYANOPHENYL)-6-PYRIDINYLPYRIMIDINE MGLU5 MODULATORS GRM5, GRM6, GRM2 MEN1 4742/4885KMT2A 1402/4885CYP1A2 1505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.