Tonabersat

Tonabersat

SCHEMBL29370960

[2H]C([2H])([2H])C1(C([2H])([2H])[2H])Oc2ccc(C(C)=O)cc2[C@H](NC(=O)c2ccc(F)c(Cl)c2)[C@@H]1O

nearest known ligand 0.87

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 5/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tonabersat SCHEMBL15973365 1.00 ABCC9 (0.54) ABCC9
Tonabersat SCHEMBL29717099 0.93 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL260661 0.93 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL29373962 0.93 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL7169677 0.93 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL5917016 0.93 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL29377931 0.93 ABCC9 (0.62) ABCC9
SCHEMBL15546692 0.83 ABCC9 (0.48) ABCC9
SCHEMBL15546693 0.83 ABCC9 (0.48) ABCC9
SCHEMBL7044135 0.82 ABCC9 (0.59) ABCC9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4677087-A1 NOVEL TREATMENTS FOR OCULAR DISORDERS Glaukos Corporation (US) 2026-01-14 EP disclosed
CN-119300817-A Compositions and methods for modulating epithelial-mesenchymal transition 奥克兰联合服务有限公司 2025-01-10 CN disclosed
WO-2024187046-A1 NOVEL TREATMENTS FOR OCULAR DISORDERS AMBER OPHTHALMICS, INC. (US) 2024-09-12 WO disclosed
EP-4301381-A1 COMPOSITIONS AND METHODS FOR MODULATING EPITHELIAL-MESENCHYMAL TRANSITION Auckland Uniservices Limited (NZ) 2024-01-10 EP disclosed
WO-2022187387-A9 COMPOSITIONS AND METHODS FOR MODULATING EPITHELIAL-MESENCHYMAL TRANSITION AUCKLAND UNISERVICES LIMITED (NZ) 2023-10-05 WO disclosed
WO-2022187387-A1 COMPOSITIONS AND METHODS FOR MODULATING EPITHELIAL-MESENCHYMAL TRANSITION AUCKLAND UNISERVICES LIMITED (NZ) 2022-09-09 WO disclosed
EP-4027992-A1 COMPOSITIONS AND METHODS FOR RESCUING RETINAL AND CHOROIDAL STRUCTURE AND FUNCTION Auckland Uniservices Limited (NZ) 2022-07-20 EP disclosed
CN-114727981-A Compositions and methods for rescuing retinal and choroidal structures and functions 奥克兰联合服务有限公司 2022-07-08 CN disclosed
EP-3958886-A1 COMPOSITIONS AND METHODS FOR PROTECTING EPITHELIAL AND BARRIER INTEGRITY Ocunexus Therapeutics, Inc. (US) 2022-03-02 EP disclosed
CN-114010788-A Channel modulators 奥克兰联合服务有限公司 2022-02-08 CN disclosed
CN-114025786-A Compositions and methods for protecting epithelial and barrier integrity 欧耐柯萨斯医疗有限公司 2022-02-08 CN disclosed