Tonabersat

Tonabersat

SCHEMBL260661

CC(=O)c1ccc2c(c1)C(NC(=O)c1ccc(F)c(Cl)c1)C(O)C(C)(C)O2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ABCC9 O60706 5/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tonabersat SCHEMBL29377931 1.00 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL29373962 1.00 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL7169677 1.00 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL5917016 1.00 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL29717099 1.00 ABCC9 (0.62) ABCC9
Tonabersat SCHEMBL29370960 0.93 ABCC9 (0.54) ABCC9
Tonabersat SCHEMBL15973365 0.93 ABCC9 (0.54) ABCC9
SCHEMBL7044135 0.89 ABCC9 (0.59) ABCC9
SCHEMBL15546692 0.88 ABCC9 (0.48) ABCC9
SCHEMBL15546693 0.88 ABCC9 (0.48) ABCC9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 895 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091017-A1 TREATMENTS FOR INFLAMMATION AUCKLAND UNISERVICES LTD (NZ) 2026-04-02 US claimed
EP-4677087-A1 NOVEL TREATMENTS FOR OCULAR DISORDERS Glaukos Corporation (US) 2026-01-14 EP claimed
US-20250352508-A1 PREVENTION AND TREATMENT OF POST-ACUTE INFECTION SYNDROMES INFLAMMX THERAPEUTICS INC (US) 2025-11-20 US claimed
WO-2025043297-A1 METHOD OF TREATING MYOPIA MCFADDEN SALLY (AU) 2025-03-06 WO claimed
US-12226393-B2 Neuroprotective compounds for amyotrophic lateral sclerosis THE JOHNS HOPKINS UNIVERSITY (US) 2025-02-18 US claimed
EP-4491184-A2 CHANNEL MODULATORS Auckland Uniservices Limited (NZ) 2025-01-15 EP claimed
CN-119300817-A Compositions and methods for modulating epithelial-mesenchymal transition 奥克兰联合服务有限公司 2025-01-10 CN claimed
EP-3183346-B1 CHANNEL MODULATORS AUCKLAND UNISERVICES LTD (NZ) 2024-10-23 EP claimed
US-12102653-B2 Ligand regulated protein-protein interaction system ST. ANNA KINDERKREBSFORSCHUNG (AT) 2024-10-01 US claimed
WO-2024187046-A1 NOVEL TREATMENTS FOR OCULAR DISORDERS AMBER OPHTHALMICS, INC. (US) 2024-09-12 WO claimed
JP-2011507800-A 2011-03-10 JP claimed
EP-2254577-A1 AMPA RECEPTOR ANTAGONISTS FOR EPILEPSY, MENTAL DISORDERS OR DEFICITS IN SENSORY ORGAN Eisai R&D Management Co., Ltd. (JP) 2010-12-01 EP claimed
US-20100297181-A1 AMPA Receptor Antagonists for Epilepsy, Mental Disorders or Deficits in Sensory Organ EISAI R&D MANAGEMENT CO., LTD. (JP) 2010-11-25 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
WO-2009147441-A2 NOVEL TREATMENTS MINSTER RESEARCH LIMITED (GB) 2009-12-10 WO claimed
WO-2009147442-A1 NOVEL TREATMENTS MINSTER RESEARCH LIMITED (GB) 2009-12-10 WO claimed
WO-2009082039-A1 AMPA RECEPTOR ANTAGONISTS FOR EPILEPSY, MENTAL DISORDERS OR DEFICITS IN SENSORY ORGAN EISAI R & D MANAGEMENT CO., LTD. (JP) 2009-07-02 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
WO-2003024456-A1 METHODS FOR TREATING AND PREVENTING MIGRAINES EISAI CO., LTD. (JP) 2003-03-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091017-A1 TREATMENTS FOR INFLAMMATION P2RX7, NLRP3, PYCARD ABCC9 98/4885
US-20250352508-A1 PREVENTION AND TREATMENT OF POST-ACUTE INFECTION SYNDROMES NLRP3, GJA1, PYCARD ABCC9 270/4885
US-12226393-B2 Neuroprotective compounds for amyotrophic lateral sclerosis NLN, SMN1; SMN2, SOD1 ABCC9 381/4885
US-20100297181-A1 AMPA Receptor Antagonists for Epilepsy, Mental Disorders or Deficits in Sensory Organ GRIK5, GRIK4, GRIK1 ABCC9 1227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.