Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10011853 | 1.00 | HSD11B1 (0.57) | HSD11B1LMNAGAAHTTALDH1A1 | |
| SCHEMBL4345873 | 0.85 | HSD11B1 (0.44) | HSD11B1LMNAGAAHTTALDH1A1 | |
| SCHEMBL22599822 | 0.84 | HSD11B1 (0.46) | HSD11B1LMNAGAAHTTALDH1A1 | |
| SCHEMBL25412393 | 0.81 | LMNA (0.38) | HSD11B1LMNAGAAHTTALDH1A1 | |
| SCHEMBL4348022 | 0.80 | HSP90AA1 (0.47) | HSD11B1ALDH1A1KDM4EHSP90AA1HSP90AB1 | |
| SCHEMBL4345607 | 0.79 | ALDH1A1 (0.76) | HSD11B1LMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4520093 | 0.77 | ALDH1A1 (0.45) | LMNAGAAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL21791710 | 0.76 | HSD11B1 (0.57) | HSD11B1LMNAGAAHTTALDH1A1 | |
| SCHEMBL21164755 | 0.76 | HSD11B1 (0.57) | HSD11B1LMNAGAAHTTALDH1A1 | |
| SCHEMBL10012289 | 0.76 | HSD11B1 (0.57) | HSD11B1LMNAGAAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260041672-A1 | Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators, Pharmaceutical Compositions, and Uses Thereof | UNIV EMORY (US) | 2026-02-12 | — | — | US | disclosed |
| EP-4188365-A2 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) MODULATORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Emory University (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2022026863-A2 | CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) MODULATORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | EMORY UNIVERSITY (US) | 2022-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260041672-A1 | Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators, Pharmaceutical Compositions, and Uses Thereof | CFTR, SCNN1B, CLCN2 | HSD11B1 1886/4885LMNA 4044/4885GAA 3553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.