Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.36 |
| ▸ | NPC1 | O15118 | 10/20 | 0.36 |
| ▸ | APP | P05067 | 4/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.36 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372842 | 0.74 | APP (0.52) | RAB9ANPC1APPPAX8SMN1; SMN2 | |
| SCHEMBL29373996 | 0.74 | SCN10A (0.40) | RAB9ANPC1APPPAX8SMN1; SMN2 | |
| SCHEMBL29372978 | 0.74 | RAB9A (0.59) | RAB9ANPC1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL24231634 | 0.74 | FLT3 (0.46) | — | |
| SCHEMBL29370489 | 0.74 | FLT3 (0.46) | — | |
| SCHEMBL29370077 | 0.73 | RAB9A (0.35) | RAB9ANPC1APPPAX8SMN1; SMN2 | |
| SCHEMBL30638526 | 0.72 | HTR7 (0.33) | — | |
| SCHEMBL29373656 | 0.70 | BACE1 (0.50) | RAB9ANPC1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL29683133 | 0.68 | TGFBR1 (0.33) | RAB9ANPC1SMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL29539234 | 0.68 | CCR1 (0.46) | RAB9ASMN1; SMN2KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026935-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-02-03 | — | — | WO | disclosed |