SCHEMBL29372796

SCHEMBL29372796

CCOC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
SMN1; SMN2 Q16637 4/20 0.42
PDE4B Q07343 1/20 0.42
DHODH Q02127 2/20 0.41
HSD11B1 P28845 1/20 0.41
POLB P06746 2/20 0.39
KDM4E B2RXH2 3/20 0.39
NPC1 O15118 2/20 0.39
MAPT P10636 2/20 0.39
RAB9A P51151 2/20 0.39
MAPK1 P28482 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
JMJD6 Q6NYC1 1/20 0.38
BRD4 O60885 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1762554 1.00 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2PDE4BDHODHHSD11B1
SCHEMBL951462 0.88 SMN1; SMN2 (0.52) ALDH1A1SMN1; SMN2PDE4BHSD11B1POLB
SCHEMBL23032142 0.88 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2POLBKDM4ENPC1
SCHEMBL29558577 0.88 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2PDE4BHSD11B1POLB
SCHEMBL1762446 0.88 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2PDE4BHSD11B1POLB
SCHEMBL592053 0.88 KDM4E (0.43) ALDH1A1SMN1; SMN2DHODHPOLBKDM4E
SCHEMBL30234432 0.87 SMN1; SMN2 (0.49) ALDH1A1SMN1; SMN2PDE4BHSD11B1POLB
SCHEMBL25702840 0.87 SMN1; SMN2 (0.49) ALDH1A1SMN1; SMN2PDE4BHSD11B1POLB
SCHEMBL29860005 0.87 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2PDE4BHSD11B1POLB
SCHEMBL950958 0.87 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2PDE4BHSD11B1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115135641-B Process for preparing 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylic acid ethyl ester FMC公司 2024-05-24 CN claimed
CN-114790190-B Purification method of 3-bromo-1- (3-chloropyridine-2-yl) -1H-pyrazole-5-ethyl formate 内蒙古灵圣作物科技有限公司 2024-03-22 CN claimed
CN-115738907-A 3-bromo-1- (3-chloro-2-pyridyl) -1H-pyrazole-5-formic acid production system and process thereof 安徽中山化工有限公司 2023-03-07 CN claimed
EP-4087839-A1 METHODS FOR THE PREPARATION OF ETHYL 3-BROMO-1-(3-CHLOROPYRIDIN-2-YL)-1H-PYRAZOLE-5-CARBOXYLATE FMC CORPORATION (US) 2022-11-16 EP claimed
CN-115135641-A Process for the preparation of ethyl 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylate FMC公司 2022-09-30 CN claimed
CN-114790190-A Purification method of 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-ethyl formate 内蒙古灵圣作物科技有限公司 2022-07-26 CN claimed
EP-4017847-A1 PROCESS FOR THE PREPARATION OF CARBOXYLIC ACID DERIVATIVES OF 3-BROMO-4,5-DIHYDRO-1H-PYRAZOLES FMC CORPORATION (US) 2022-06-29 EP claimed
CN-114341126-A Process for preparing carboxylic acid derivatives of 3-halo-4, 5-dihydro-1H-pyrazole FMC公司 2022-04-12 CN claimed
EP-4017847-B1 PROCESS FOR THE PREPARATION OF CARBOXYLIC ACID DERIVATIVES OF 3-BROMO-4,5-DIHYDRO-1H-PYRAZOLES FMC CORP (US) 2025-10-01 EP disclosed
CN-114341126-B Process for preparing carboxylic acid derivatives of 3-halo-4, 5-dihydro-1H-pyrazoles FMC公司 2025-04-25 CN disclosed
CN-114787141-B Process for preparing 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylic acid ethyl ester FMC公司 2024-07-09 CN disclosed
CN-114787141-B Process for preparing 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylic acid ethyl ester FMC公司 2024-07-09 CN disclosed
CN-114787141-B Process for preparing 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylic acid ethyl ester FMC公司 2024-07-09 CN disclosed
CN-115135641-B Process for preparing 3-bromo-1- (3-chloropyridin-2-yl) -1H-pyrazole-5-carboxylic acid ethyl ester FMC公司 2024-05-24 CN disclosed
CN-114516855-A Preparation of pyridylpyrazole amide compounds and intermediates therefor 湖南化工研究院有限公司 2022-05-20 CN disclosed
CN-114341126-A Process for preparing carboxylic acid derivatives of 3-halo-4, 5-dihydro-1H-pyrazole FMC公司 2022-04-12 CN disclosed
EP-3976596-A1 METHODS FOR THE PREPARATION OF ETHYL 3-BROMO-1-(3-CHLOROPYRIDIN-2-YL)-1H-PYRAZOLE-5-CARBOXYLATE FMC Corporation (US) 2022-04-06 EP disclosed
EP-3976596-A1 METHODS FOR THE PREPARATION OF ETHYL 3-BROMO-1-(3-CHLOROPYRIDIN-2-YL)-1H-PYRAZOLE-5-CARBOXYLATE FMC Corporation (US) 2022-04-06 EP disclosed
EP-3976596-A1 METHODS FOR THE PREPARATION OF ETHYL 3-BROMO-1-(3-CHLOROPYRIDIN-2-YL)-1H-PYRAZOLE-5-CARBOXYLATE FMC Corporation (US) 2022-04-06 EP disclosed
CN-114011370-A Equipment for efficiently producing pyrazolecarboxylic acid and improvement method thereof 江苏优普生物化学科技股份有限公司 2022-02-08 CN disclosed