Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.58 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 7/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19368821 | 0.87 | KEAP1 (0.67) | KEAP1CPB2DAORETDYRK1A | |
| SCHEMBL2049672 | 0.78 | KEAP1 (0.68) | KEAP1CPB2DAORETDYRK1A | |
| SCHEMBL74518 | 0.78 | KEAP1 (0.68) | KEAP1CPB2DAORETDYRK1A | |
| SCHEMBL29373664 | 0.77 | NAMPT (0.40) | KEAP1CPB2NAMPTMASP2 | |
| SCHEMBL1500299 | 0.77 | KEAP1 (0.54) | KEAP1CPB2DAORETDYRK1A | |
| SCHEMBL19764528 | 0.76 | KEAP1 (0.57) | KEAP1CPB2DAODYRK1AMERTK | |
| Ammonia Solution, Strong SCHEMBL28922912 | 0.76 | KEAP1 (0.66) | KEAP1CPB2DAORETDYRK1A | |
| SCHEMBL31370539 | 0.76 | CPB2 (0.58) | KEAP1CPB2DAORETNAMPT | |
| SCHEMBL19973166 | 0.75 | KEAP1 (0.48) | KEAP1CPB2DAORETDYRK1A | |
| SCHEMBL24484881 | 0.75 | KEAP1 (0.64) | KEAP1CPB2DAORETDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| CN-118613480-A | Polycyclic IRAK and FLT3 inhibiting compounds and uses thereof | 儿童医院医学中心 | 2024-09-06 | — | — | CN | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |
| WO-2022026935-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-02-03 | — | — | WO | disclosed |