Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 9/20 | 0.39 |
| ▸ | AXL | P30530 | 8/20 | 0.38 |
| ▸ | FLT3 | P36888 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19368821 | 0.80 | KEAP1 (0.67) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL29372807 | 0.77 | KEAP1 (0.58) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL18297160 | 0.76 | KEAP1 (0.62) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL24494597 | 0.74 | KEAP1 (0.68) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL74518 | 0.74 | KEAP1 (0.68) | KEAP1CPB2DAODYRK1AMERTK | |
| Ammonia Solution, Strong SCHEMBL28922912 | 0.73 | KEAP1 (0.66) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL19973166 | 0.71 | KEAP1 (0.48) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL24484881 | 0.71 | KEAP1 (0.64) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL14638413 | 0.71 | KEAP1 (0.68) | KEAP1CPB2DAODYRK1AMERTK | |
| SCHEMBL6092812 | 0.71 | KEAP1 (1.00) | KEAP1CPB2DAODYRK1AMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160208-A1 | DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-06-30 | — | — | US | disclosed |
| US-7902369-B2 | Diaryl-substituted five-membered heterocycle derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-03-08 | — | — | US | disclosed |
| US-20070173507-A1 | Dairyl-substituted five-membered heterocycle derivative | MSD K.K. (JP) | 2007-07-26 | — | — | US | disclosed |
| EP-1726585-A1 | DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160208-A1 | DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE | OPRK1, GRM1, GRIK1 | KEAP1 1409/4885CPB2 4361/4885DAO 2368/4885 |
| US-20070173507-A1 | Dairyl-substituted five-membered heterocycle derivative | OPRK1, OPRL1, GRM1 | KEAP1 1217/4885CPB2 4227/4885DAO 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.