Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937788 | 0.77 | MAPK1 (0.50) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2937786 | 0.77 | MAPK1 (0.50) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3801239 | 0.77 | SMN1; SMN2 (0.44) | MAPTNPSR1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3799754 | 0.73 | THRB (0.52) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18562544 | 0.72 | TSHR (0.55) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2938027 | 0.72 | HRH3 (0.46) | MAPTCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL11852169 | 0.72 | MAPK1 (0.50) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11852183 | 0.72 | MAPK1 (0.50) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7035586 | 0.68 | THRB (0.52) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2028840 | 0.68 | LMNA (0.46) | MAPTLMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120316201-A1 | NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA S.A.S. (FR) | 2012-12-13 | — | — | US | disclosed |
| US-8227485-B2 | Benzimidazole and imidazopyridine derivatives and use thereof as a medicament | IPSEN PHARMA S.A.S. (FR) | 2012-07-24 | — | — | US | disclosed |
| US-7816539-B2 | Derivatives of benzimidazole and imidazo-pyridine and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2010-10-19 | — | — | US | disclosed |
| EP-1692114-B1 | NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | IPSEN PHARMA (FR) | 2010-09-22 | — | — | EP | disclosed |
| US-20090270372-A1 | NOVEL DERIVATIVES OF BENZIMIDAZOLE AND IMIDAZO-PYRIDINE AND THEIR USE AS MEDICAMENTS | SOCIETE DE CONSEILS DE RECHERCHES ET (FR) | 2009-10-29 | — | — | US | disclosed |
| US-7501524-B2 | Derivatives of benzimidazole and imidazo-pyridine and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2009-03-10 | — | — | US | disclosed |
| US-7501525-B2 | Derivatives of benzimidazole and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2009-03-10 | — | — | US | disclosed |
| US-20080139619-A1 | Novel derivatives of benzimidazale and imidazo-pyridine and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS (S.C.R.A.S.) | 2008-06-12 | — | — | US | disclosed |
| US-7355052-B2 | Benzimidazole and imidazopyridine derivatives and use thereof as a medicament | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2008-04-08 | — | — | US | disclosed |
| EP-1599167-B1 | BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES HAVING AFFINITY FOR THE MELANOCORTIN RECEPTORS AND USE THEREOF AS A MEDICAMENT | SOD CONSEILS RECH APPLIC (FR) | 2007-10-03 | — | — | EP | disclosed |
| US-20060281784-A1 | Novel benzimidazole and imidazopyridine derivatives and use thereof as a medicament | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) | 2006-12-14 | — | — | US | disclosed |
| EP-1692114-A1 | NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2006-08-23 | — | — | EP | disclosed |
| US-20050267147-A1 | Novel benzimidazole and imidazopyridine derivatives and use thereof as a medicament | IPSEN PHARMA S.A.S. (FR) | 2005-12-01 | — | — | US | disclosed |
| EP-1599167-A2 | NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2005056533-A1 | NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2005-06-23 | — | — | WO | disclosed |
| US-20050065179-A1 | Novel derivatives of benzimidazole and imidazo-pyridine and their use as medicaments | IPSEN PHARMA S.A.S. (FR) | 2005-03-24 | — | — | US | disclosed |
| WO-2004075823-A2 | NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270372-A1 | NOVEL DERIVATIVES OF BENZIMIDAZOLE AND IMIDAZO-PYRIDINE AND THEIR USE AS MEDICAMENTS | MC4R, MC3R, MC1R | MAPT 2697/4885LMNA 4306/4885CYP1A2 1950/4885 |
| US-20050065179-A1 | Novel derivatives of benzimidazole and imidazo-pyridine and their use as medicaments | MC1R, MC4R, MC3R | MAPT 1723/4885LMNA 4259/4885CYP1A2 1383/4885 |
| US-20050267147-A1 | Novel benzimidazole and imidazopyridine derivatives and use thereof as a medicament | MC4R, MC1R, MC5R | MAPT 1838/4885LMNA 4394/4885CYP1A2 1107/4885 |
| US-20080139619-A1 | Novel derivatives of benzimidazale and imidazo-pyridine and their use as medicaments | MC4R, MC1R, MC3R | MAPT 3226/4885LMNA 4195/4885CYP1A2 2187/4885 |
| US-20120316201-A1 | NOVEL BENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS A MEDICAMENT | MC4R, MC5R, MC1R | MAPT 2678/4885LMNA 4626/4885CYP1A2 672/4885 |
| US-20060281784-A1 | Novel benzimidazole and imidazopyridine derivatives and use thereof as a medicament | MC4R, MC5R, MC1R | MAPT 2729/4885LMNA 4552/4885CYP1A2 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.