SCHEMBL29373530

SCHEMBL29373530

C=CC(=O)N1CCN(c2ncnc3c(F)c(-c4c(O)cccc4F)c(Cl)cc23)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KRAS P01116 20/20 1.00
EGFR P00533 1/20 1.00
HMOX2 P30519 1/20 1.00
CRYZ Q08257 1/20 1.00
VAT1 Q99536 1/20 1.00
RTN4 Q9NQC3 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29379971 1.00 KRAS (1.00) KRASEGFRHMOX2CRYZVAT1
SCHEMBL16637284 1.00 KRAS (1.00) KRASEGFRHMOX2CRYZVAT1
SCHEMBL31658077 0.97 KRAS (0.93) KRASEGFRHMOX2CRYZVAT1
SCHEMBL18128690 0.97 KRAS (0.93) KRASEGFRHMOX2CRYZVAT1
SCHEMBL29765662 0.94 KRAS (0.88) KRASEGFRHMOX2CRYZVAT1
SCHEMBL16647182 0.94 KRAS (0.88) KRASEGFRHMOX2CRYZVAT1
SCHEMBL29766035 0.92 KRAS (0.84) KRASEGFRHMOX2CRYZVAT1
SCHEMBL16646915 0.92 KRAS (0.84) KRASEGFRHMOX2CRYZVAT1
SCHEMBL18842314 0.91 KRAS (0.83) KRASEGFRHMOX2CRYZVAT1
SCHEMBL21471922 0.90 KRAS (0.82) KRASEGFRHMOX2CRYZVAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1287 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260130891-A1 PIM KINASE INHIBITOR IN COMBINATION WITH KRAS INHIBITOR NINGBO NEWBAY TECH DEVELOPMENT CO LTD (CN) 2026-05-14 US claimed
US-20260109786-A1 CHEMICALLY CONTROLLED MONOCLONAL ANTIBODY TARGET ENGAGEMENT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-04-23 US claimed
US-12605383-B2 Methods of treating cancer University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2026-04-21 US claimed
US-20260102528-A1 BINDING AGENT RECOGNITION OF DRUG-PEPTIDE CONJUGATES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-04-16 US claimed
EP-4719410-A1 FARNESYLTRANSFERASE INHIBITORS FOR TREATMENT OF KRAS-DEPENDENT CANCERS Kura Oncology, Inc. (US) 2026-04-08 EP claimed
US-12486334-B2 Chemically controlled monoclonal antibody target engagement THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-12-02 US claimed
US-20250353912-A1 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES UNIV NEW YORK (US) 2025-11-20 US claimed
WO-2025226775-A2 COMPOSITIONS AND METHODS FOR BINDING TO COVALENT PEPTIDE CONJUGATES NEW YORK UNIVERSITY (US) 2025-10-30 WO claimed
EP-4637832-A1 CONJUGATES COMPRISING A PHOSPHORUS(V) MOIETY AND A DRUG Tubulis GmbH (DE) 2025-10-29 EP claimed
EP-4635574-A2 COMBINATION THERAPY TO TREAT KRAS MUTANT CANCERS Semmelweis Egyetem (HU) 2025-10-22 EP claimed
WO-2022183112-A2 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES NEW YORK UNIVERSITY (US) 2022-09-01 WO claimed
CN-114901286-A Combination therapy involving diaryl macrocycle compounds 特普医药公司 2022-08-12 CN claimed
EP-4010081-A1 COMBINATION THERAPY FOR TREATMENT OF CANCER Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center (US) 2022-06-15 EP claimed
WO-2022119349-A1 COMPOSITION FOR SUPPRESSING RESISTANCE TO KRAS INHIBITOR 울산대학교 산학협력단 2022-06-09 WO claimed
WO-2022115767-A1 METHODS OF TREATING CANCER UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2022-06-02 WO claimed
EP-3997131-A1 CHEMICALLY CONTROLLED MONOCLONAL ANTIBODY TARGET ENGAGEMENT The Regents of the University of California (US) 2022-05-18 EP claimed
US-20220112308-A1 KRAS SPECIFIC ANTIBODIES AND USES THEREOF GENENTECH, INC. (US) 2022-04-14 US claimed
WO-2022031952-A9 TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS CITY OF HOPE (US) 2022-04-07 WO claimed
WO-2022060583-A1 USE OF SOS1 INHIBITORS TO TREAT MALIGNANCIES WITH SHP2 MUTATIONS Revolution Medicines, Inc. (US) 2022-03-24 WO claimed
WO-2022031952-A2 TREATMENTS FOR CANCERS HAVING KRAS MUTATIONS CITY OF HOPE (US) 2022-02-10 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109786-A1 CHEMICALLY CONTROLLED MONOCLONAL ANTIBODY TARGET ENGAGEMENT SET, TNFSF11, TNFSF10 KRAS 849/4885EGFR 62/4885HMOX2 4308/4885
US-20260102528-A1 BINDING AGENT RECOGNITION OF DRUG-PEPTIDE CONJUGATES IGSF11, PDCD1LG2, CD79B KRAS 1214/4885EGFR 962/4885HMOX2 4138/4885
US-20260130891-A1 PIM KINASE INHIBITOR IN COMBINATION WITH KRAS INHIBITOR KRAS, PIM1, PIM3 KRAS 1/4885EGFR 121/4885HMOX2 2454/4885
US-12605383-B2 Methods of treating cancer IL36G, IL2RA, TP53 KRAS 4/4885EGFR 20/4885HMOX2 3289/4885
US-20250353912-A1 COMPOSITIONS AND METHODS COMPRISING ANTIBODIES THAT BIND TO COVALENT PEPTIDE CONJUGATES MICA, CD74, HLA-DRB1 KRAS 2277/4885EGFR 2295/4885HMOX2 4242/4885
US-12486334-B2 Chemically controlled monoclonal antibody target engagement TP53, CD47, BCR KRAS 51/4885EGFR 28/4885HMOX2 3517/4885
US-20220112308-A1 KRAS SPECIFIC ANTIBODIES AND USES THEREOF KRAS, NRAS, HRAS KRAS 1/4885EGFR 137/4885HMOX2 4573/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.