Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.79 |
| ▸ | USP2 | O75604 | 3/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.79 |
| ▸ | LCK | P06239 | 2/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.79 |
| ▸ | RECQL | P46063 | 2/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.79 |
| ▸ | EGFR | P00533 | 1/20 | 0.79 |
| ▸ | FYN | P06241 | 1/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.79 |
| ▸ | HTR2A | P28223 | 1/20 | 0.79 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | XIAP | P98170 | 1/20 | 0.56 |
| ▸ | KDM6B | O15054 | 1/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL245058 | 0.91 | SLC7A5 (0.90) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL28214733 | 0.91 | SLC7A5 (0.90) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL245057 | 0.91 | SLC7A5 (0.90) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL27841673 | 0.91 | SLC7A5 (0.96) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL896629 | 0.89 | SLC7A5 (0.87) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL27642065 | 0.89 | SLC7A5 (0.87) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL116907 | 0.89 | SLC7A5 (1.00) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL11000382 | 0.89 | SLC7A5 (1.00) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL22655 | 0.89 | SLC7A5 (1.00) | SLC7A5USP2PTGS1LCKKDM4E | |
| Levodopa SCHEMBL20582239 | 0.89 | SLC7A5 (1.00) | SLC7A5USP2PTGS1LCKKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4318663-A1 | CIRCUIT BOARD ASSEMBLY | NGK Insulators, Ltd. (JP) | 2024-02-07 | — | — | EP | disclosed |
| US-20240008185-A1 | CIRCUIT BOARD ASSEMBLY | NGK INSULATORS, LTD. (JP) | 2024-01-04 | — | — | US | disclosed |
| EP-3951934-A1 | LITHIUM COMPOSITE OXIDE SINTERED BODY PLATE | NGK Insulators, Ltd. (JP) | 2022-02-09 | — | — | EP | disclosed |