SCHEMBL29375272

SCHEMBL29375272

CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)O

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
IL1RN P18510 1/20 0.54
ERAP2 Q6P179 1/20 0.54
NPY4R P50391 11/20 0.54
NPY1R P25929 8/20 0.54
NPY2R P49146 6/20 0.54
NPY5R Q15761 5/20 0.54
OPRM1 P35372 2/20 0.52
OPRD1 P41143 2/20 0.52
OPRK1 P41145 1/20 0.52
BACE1 P56817 2/20 0.51
BACE2 Q9Y5Z0 2/20 0.51
EGFR P00533 1/20 0.50
KISS1R Q969F8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29728788 0.98 OPRM1 (0.55) IL1RNERAP2NPY4RNPY1RNPY2R
SCHEMBL29375823 0.92 IL1RN (0.55) IL1RNERAP2NPY4RNPY1RNPY2R
SCHEMBL2195747 0.92 IL1RN (0.56) IL1RNERAP2NPY4RNPY1RNPY2R
SCHEMBL29373148 0.91 BACE1 (0.60) OPRM1OPRD1OPRK1BACE1BACE2
SCHEMBL30558097 0.90 KISS1R (0.52) NPY4RNPY1RNPY2RNPY5ROPRD1
SCHEMBL30124163 0.90 IL1RN (0.52) IL1RNERAP2NPY4RNPY1RNPY2R
SCHEMBL30070212 0.89 NPY4R (0.67) NPY4RNPY1RNPY2ROPRM1OPRD1
SCHEMBL30124150 0.89 NPY4R (0.58) IL1RNERAP2NPY4RNPY1RNPY2R
SCHEMBL29375830 0.88 BACE1 (0.59) OPRM1OPRD1OPRK1BACE1BACE2
SCHEMBL30473779 0.88 NPY4R (0.60) IL1RNERAP2NPY4RNPY1RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117098843-A Subtilisin variants and uses thereof 费森尤斯卡比有限公司 2023-11-21 CN claimed
EP-3864032-B1 PROCESS FOR THE MANUFACTURE OF GLP-1 ANALOGUES FRESENIUS KABI IPSUM S R L (IT) 2022-11-30 EP claimed
US-11396533-B2 Process for the manufacture of GLP-1 analogues Fresenius Kabi Ipsum S.R.L. (IT) 2022-07-26 US claimed
US-20220041680-A1 PROCESS FOR THE MANUFACTURE OF GLP-1 ANALOGUES Fresenius Kabi Ipsum S.R.L. (IT) 2022-02-10 US claimed
CN-119060201-A Chemoenzymatic synthesis of liraglutide, soxhlet Ma Lutai and GLP-1 费森尤斯卡比有限公司 2024-12-03 CN disclosed
WO-2024231312-A2 COMBINATION THERAPY UNION therapeutics A/S (DK) 2024-11-14 WO disclosed
WO-2024175930-A1 COMPOUNDS IP2IPO INNOVATIONS LIMITED (GB) 2024-08-29 WO disclosed
CN-111819191-B Chemoenzymatic synthesis of liraglutide, soxhlet Ma Lutai and GLP-1 费森尤斯卡比有限公司 2024-08-20 CN disclosed
CN-112912390-B GLP-1 analogues and methods of preparation 北京费森尤斯卡比医药有限公司 2023-12-15 CN disclosed
EP-4259646-A1 NOVEL COMPOUNDS IP2IPO Innovations Limited (GB) 2023-10-18 EP disclosed
CN-116836258-A Solid phase synthesis method of liraglutide 辽宁药联制药有限公司 2023-10-03 CN disclosed
EP-4196495-A1 EXENDIN-4 PEPTIDE ANALOGUES TXP Pharma GmbH (CH) 2023-06-21 EP disclosed
EP-3864032-B1 PROCESS FOR THE MANUFACTURE OF GLP-1 ANALOGUES FRESENIUS KABI IPSUM S R L (IT) 2022-11-30 EP disclosed
US-11396533-B2 Process for the manufacture of GLP-1 analogues Fresenius Kabi Ipsum S.R.L. (IT) 2022-07-26 US disclosed
WO-2022123271-A1 NOVEL COMPOUNDS IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) 2022-06-16 WO disclosed
WO-2022034062-A1 EXENDIN-4 PEPTIDE ANALOGUES TXP PHARMA AG (CH) 2022-02-17 WO disclosed
US-20220041680-A1 PROCESS FOR THE MANUFACTURE OF GLP-1 ANALOGUES Fresenius Kabi Ipsum S.R.L. (IT) 2022-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220041680-A1 PROCESS FOR THE MANUFACTURE OF GLP-1 ANALOGUES GLP1R, IAPP, VIP IL1RN 840/4885ERAP2 1697/4885NPY4R 8/4885
US-11396533-B2 Process for the manufacture of GLP-1 analogues GLP1R, IAPP, VIP IL1RN 840/4885ERAP2 1697/4885NPY4R 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.