Tretazicar

Tretazicar

SCHEMBL29375352

NC(=O)c1cc(N2CC2)c([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 1.00
CYP3A4 P08684 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
ALDH1A1 P00352 10/20 0.54
GAA P10253 4/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
PKM P14618 1/20 0.54
HTT P42858 3/20 0.51
LMNA P02545 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
SMN1; SMN2 Q16637 4/20 0.50
CTPS1 P17812 1/20 0.49
POLB P06746 1/20 0.49
NPC1 O15118 1/20 0.46
NOD1 Q9Y239 1/20 0.46
GPR174 Q9BXC1 1/20 0.45
MAPK1 P28482 1/20 0.44
TDP1 Q9NUW8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tretazicar SCHEMBL366755 1.00 MAPT (1.00) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL13685668 0.88 MAPT (0.78) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL5581335 0.88 MAPT (0.78) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL5827945 0.88 MAPT (0.78) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL3492841 0.86 MAPT (0.75) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL11120951 0.85 MAPT (0.74) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL3362694 0.84 MAPT (0.72) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL446497 0.84 MAPT (0.72) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL29391567 0.84 MAPT (0.72) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL3678573 0.84 MAPT (0.72) MAPTCYP3A4BLMPMP22ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 382 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4602052-A1 PROTEIN-BASED SIGNAL AMPLIFICATION California Institute of Technology (US) 2025-08-20 EP claimed
US-12297241-B2 Method to engineer transplantable human tissues THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-05-13 US claimed
WO-2025097124-A1 MOLECULAR SWITCH FOR INDUCIBLE GENE EXPRESSION THE BRIGHAM AND WOMEN’S HOSPITAL, INC. (US) 2025-05-08 WO claimed
WO-2025084267-A1 TRANSFORMANT AND METHOD FOR PRODUCING TARGET PROTEIN 学校法人東京理科大学 2025-04-24 WO claimed
EP-4466354-A2 TRANS-SPLICING RNA (TSRNA) National University of Singapore (SG) 2024-11-27 EP claimed
CN-118786214-A Trans-splicing RNA (tsRNA) 新加坡国立大学 2024-10-15 CN claimed
US-20240285804-A1 ADENO-ASSOCIATED VIRAL (AAV) VECTORS FOR TISSUE-TARGETED EXPRESSION OF THERAPEUTIC GENES BRIGHAM & WOMENS HOSPITAL INC (US) 2024-08-29 US claimed
EP-4419692-A2 SYNTHETIC INTRONS FOR TARGETED GENE EXPRESSION Fred Hutchinson Cancer Center (US) 2024-08-28 EP claimed
CN-118272378-A Method for maintaining stem property of pluripotent stem cells and removing residues thereof in differentiated cells 呈诺再生医学科技(北京)有限公司 2024-07-02 CN claimed
EP-4388114-A1 CELL-TO-CELL DELIVERY OF RNA CIRCUITS California Institute of Technology (US) 2024-06-26 EP claimed
WO-2022212005-A9 ACOUSTIC REMOTE CONTROL OF MICROBIAL IMMUNOTHERAPY CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2022-11-17 WO claimed
US-20220333079-A1 GENETICALLY MODIFIED NK CELL LINE TRANSDUCED WITH GENE ENCODING NOVEL CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF SLBiGen, Inc. (KR) 2022-10-20 US claimed
WO-2022212005-A2 ACOUSTIC REMOTE CONTROL OF MICROBIAL IMMUNOTHERAPY CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2022-10-06 WO claimed
CN-115151635-A Gene-modified NK cell lines transduced with genes encoding novel chimeric antigen receptors and uses thereof 斯比根公司 2022-10-04 CN claimed
CN-115054608-A Application of cryptotanshinone substances and combination composition thereof 澳门大学 2022-09-16 CN claimed
US-20220235104-A1 NOVEL METHOD TO ENGINEER TRANSLANTABLE HUMAN TISSUES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-07-28 US claimed
EP-4032972-A1 GENETICALLY MODIFIED NK CELL LINE TRANSDUCED WITH GENE ENCODING NOVEL CHIMERIC ANTIGEN RECEPTOR AND USE THEREOF Slbigen Inc. (KR) 2022-07-27 EP claimed
WO-2022125590-A1 A SYNTHETIC CIRCUIT FOR CELLULAR MULTISTABILITY CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2022-06-16 WO claimed
WO-2022087427-A1 SYNTHETIC INTRONS FOR TARGETED GENE EXPRESSION FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2022-04-28 WO claimed
WO-2022076756-A1 RECOMBINANT VIRUSES, SURFACE-ENGINEERED DELIVERY SYSTEMS AND RELATED METHODS DEVACELL, INC. (US) 2022-04-14 WO claimed