SCHEMBL446497

SCHEMBL446497

NC(=O)c1cc(N2CC2)c(NO)cc1[N+](=O)[O-]

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 10/20 0.72
CYP3A4 P08684 2/20 0.72
BLM P54132 1/20 0.72
PMP22 Q01453 1/20 0.72
ALDH1A1 P00352 9/20 0.45
GAA P10253 4/20 0.45
SMN1; SMN2 Q16637 4/20 0.45
L3MBTL1 Q9Y468 2/20 0.45
PKM P14618 1/20 0.45
HTT P42858 3/20 0.43
LMNA P02545 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
CTPS1 P17812 1/20 0.41
POLB P06746 1/20 0.41
NPC1 O15118 1/20 0.40
NOD1 Q9Y239 1/20 0.40
MAPK1 P28482 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GALR3 O60755 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3678573 0.89 MAPT (0.72) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL6047059 0.85 MAPT (0.67) MAPTCYP3A4BLMPMP22ALDH1A1
Tretazicar SCHEMBL29375352 0.84 MAPT (1.00) MAPTCYP3A4BLMPMP22ALDH1A1
Tretazicar SCHEMBL366755 0.84 MAPT (1.00) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL13685668 0.81 MAPT (0.78) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL5581335 0.81 MAPT (0.78) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL3503280 0.81 MAPT (0.55) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL13685644 0.80 MAPT (0.58) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL29391567 0.78 MAPT (0.72) MAPTCYP3A4BLMPMP22ALDH1A1
SCHEMBL3362694 0.78 MAPT (0.72) MAPTCYP3A4BLMPMP22ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 258 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119674357-A Battery cell shell and battery cell 蜂巢能源科技股份有限公司 2025-03-21 CN claimed
EP-4186112-A1 SUPERCONDUCTING STRUCTURE AND DEVICE SURFACE TERMINATION WITH ALLOY International Business Machines Corporation (US) 2023-05-31 EP claimed
CN-107080746-B Using alpha-hydroxycarbonyl compounds as reducing agents 高典制药有限公司 2021-08-06 CN claimed
US-10398676-B2 Use of alpha-hydroxy carbonyl compounds as reducing agents MORVUS TECHNOLOGY LIMITED (GB) 2019-09-03 US claimed
US-20180140575-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS GORDIAN PHARMA LIMITED (GB) 2018-05-24 US claimed
US-9907784-B2 Use of alpha-hydroxy carbonyl compounds as reducing agents MORVUS TECHNOLOGY LIMITED (GB) 2018-03-06 US claimed
EP-2258430-B1 5-(Aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and its use in medicine MORVUS TECH LTD (GB) 2017-03-22 EP claimed
US-20150231113-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS GORDIAN PHARMA LIMITED (GB) 2015-08-20 US claimed
US-9029569-B2 Use of alpha-hydroxy carbonyl compounds as reducing agents MORVUS TECHNOLOGY LIMITED (GB) 2015-05-12 US claimed
CN-103315995-A Use of alpha-hydroxy carbonyl compounds as reducing agents MORVUS TECHNOLOGY LTD 2013-09-25 CN claimed
EP-1951213-B1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS MORVUS TECHNOLOGY LTD (GB) 2012-11-14 EP claimed
EP-2258430-A2 5-(Aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and its use in medicine Morvus Technology Ltd. (GB) 2010-12-08 EP claimed
US-20100104515-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS GORDIAN PHARMA LIMITED (GB) 2010-04-29 US claimed
WO-2009111177-A2 COMPOSITIONS AND METHODS COMPRISING GENETICALLY ENHANCED OBLIGATE AND FACULTATIVE ANAEROBIC BACTERIA FOR ONCOPATHIC CANCER THERAPY MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY (US) 2009-09-11 WO claimed
CN-101389320-A Using alpha-hydroxycarbonyl compounds as reducing agents MORVUS TECHNOLOGY LTD (GB) 2009-03-18 CN claimed
EP-1951213-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS Morvus Technology Ltd. (GB) 2008-08-06 EP claimed
WO-2007074344-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS MORVUS TECHNOLOGY LIMITED (GB) 2007-07-05 WO claimed
EP-0429454-A1 IMPROVEMENTS RELATING TO THE CONTROL OF NEOPLASTIC TISSUE GROWTH Roberts, John J. (GB) 1991-06-05 EP claimed
EP-0330432-A1 Improvements relating to the control of neoplastic tissue growth Roberts, John J. (GB) 1989-08-30 EP claimed
WO-1989007592-A1 IMPROVEMENTS RELATING TO THE CONTROL OF NEOPLASTIC TISSUE GROWTH ROBERTS JOHN J (GB) 1989-08-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100104515-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS DERA, HOGA1, ALDOA MAPT 3157/4885CYP3A4 456/4885BLM 3799/4885
US-10398676-B2 Use of alpha-hydroxy carbonyl compounds as reducing agents DERA, HOGA1, ALDOA MAPT 3157/4885CYP3A4 456/4885BLM 3799/4885
US-20180140575-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS DERA, HOGA1, ALDOA MAPT 3157/4885CYP3A4 456/4885BLM 3799/4885
US-20150231113-A1 USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS DERA, HOGA1, ALDOA MAPT 3157/4885CYP3A4 456/4885BLM 3799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.