SCHEMBL29376708

SCHEMBL29376708

O=c1cc(Nc2ccc(F)cc2F)c1=O

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 6/20 0.47
ALDH1A1 P00352 3/20 0.46
SOS1 Q07889 1/20 0.46
HTT P42858 3/20 0.42
PTGS2 P35354 1/20 0.42
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
KDM4E B2RXH2 1/20 0.41
GAA P10253 1/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
CYP2C19 P33261 2/20 0.40
AKT1 P31749 1/20 0.40
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29377177 0.76 MAPT (0.55) MAPK14ALDH1A1SOS1HTTPTGS2
SCHEMBL17110585 0.69 APP (0.55) MAPK14ALDH1A1SOS1HTTNPC1
SCHEMBL13042657 0.68 RAB9A (0.59) MAPK14ALDH1A1SOS1HTTNPC1
SCHEMBL21468597 0.68 SOS1 (0.53) MAPK14ALDH1A1SOS1HTTNPC1
SCHEMBL4511303 0.68 GAA (0.52) ALDH1A1HTTNPC1RAB9ASMN1; SMN2
SCHEMBL29581577 0.68 ALDH1A1 (0.47) MAPK14ALDH1A1SOS1HTTNPC1
SCHEMBL3606443 0.68 ALDH1A1 (0.47) MAPK14ALDH1A1SOS1HTTNPC1
SCHEMBL16489007 0.67 MAPT (0.62) ALDH1A1HTTPTGS2NPC1RAB9A
SCHEMBL3613999 0.67 SOS1 (0.44) MAPK14ALDH1A1SOS1HTTNPC1
SCHEMBL22543003 0.67 FGFR1 (0.49) MAPK14ALDH1A1SOS1HTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3953340-A1 NOVEL OXADIAZOLE COMPOUNDS FOR CONTROLLING OR PREVENTING PHYTOPATHOGENIC FUNGI PI Industries Ltd. (IN) 2022-02-16 EP claimed
CN-114026077-A Novel oxadiazole compounds for controlling or preventing phytopathogenic fungi PI工业有限公司 2022-02-08 CN claimed
CN-114026077-A Novel oxadiazole compounds for controlling or preventing phytopathogenic fungi PI工业有限公司 2022-02-08 CN disclosed