Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.74 |
| ▸ | MEN1 | O00255 | 7/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.69 |
| ▸ | ATM | Q13315 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28864313 | 0.87 | ALDH1A1 (0.95) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL3766741 | 0.85 | ALDH1A1 (0.65) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL3766736 | 0.85 | ALDH1A1 (0.65) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL19970339 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL3456878 | 0.82 | EPHX2 (0.71) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL28864301 | 0.81 | ALDH1A1 (0.61) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL15847483 | 0.81 | ALDH1A1 (0.54) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL2708121 | 0.81 | NR1H2 (0.67) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL21802550 | 0.80 | FAAH (0.69) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL29783956 | 0.80 | KDM4E (0.70) | KDM4EALDH1A1KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426441-B2 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2013-04-23 | — | — | US | claimed |
| US-20090186898-A1 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC | 2009-07-23 | — | — | US | claimed |
| US-8426441-B2 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2013-04-23 | — | — | US | disclosed |
| CN-101952283-B | Imidazo [1,2-a ] pyridine and imidazo [1,2-b ] pyridazine derivatives | HOFFMANN LA ROCHE | 2013-04-17 | — | — | CN | disclosed |
| CN-101952283-A | Novel imidazo [1,2-a ] pyridine and imidazo [1,2-b ] pyridazine derivatives | HOFFMANN LA ROCHE | 2011-01-19 | — | — | CN | disclosed |
| EP-2229390-A1 | NOVEL IMIDAZOÝ1,2-A¨PYRIDINE AND IMIDAZOÝ1,2-B¨PYRIDAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| US-20090186898-A1 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC | 2009-07-23 | — | — | US | disclosed |
| WO-2009077334-A1 | NOVEL IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186898-A1 | Inhibitors of bruton's tyrosine kinase | BTK, SYK, LYN | KDM4E 738/4885ALDH1A1 4319/4885KMT2A 1922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.