SCHEMBL29385201

SCHEMBL29385201

CCCCCC(C)c1cccnc1C(N)=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
HPGD P15428 1/20 0.39
HSD17B10 Q99714 1/20 0.39
FAAH O00519 2/20 0.38
TLR8 Q9NR97 2/20 0.37
PPARG P37231 3/20 0.37
PPARA Q07869 2/20 0.37
MEN1 O00255 1/20 0.37
NR1I2 O75469 1/20 0.37
LMNA P02545 1/20 0.37
CHRM2 P08172 1/20 0.37
CYP3A4 P08684 1/20 0.37
ADRA2A P08913 1/20 0.37
MAPT P10636 1/20 0.37
OPRK1 P41145 1/20 0.37
HTR2B P41595 1/20 0.37
SLC6A3 Q01959 1/20 0.37
KMT2A Q03164 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29117493 0.99 FAAH (0.39) KDM4EALDH1A1HPGDHSD17B10FAAH
SCHEMBL25452695 0.86 PTPN1 (0.42) KDM4EALDH1A1FAAHPPARGPPARA
SCHEMBL21274739 0.86 CYSLTR2 (0.44) KDM4EALDH1A1HPGDHSD17B10FAAH
SCHEMBL28669524 0.85 KDM4E (0.41) KDM4EALDH1A1HPGDHSD17B10FAAH
SCHEMBL30663266 0.84 PTPN1 (0.38) FAAHPPARGPPARA
SCHEMBL29117492 0.83 PTPN1 (0.40) FAAHPPARGPPARA
SCHEMBL30630403 0.83 BRD4 (0.49) KDM4EALDH1A1HSD17B10PPARGPPARA
Trifluoroacetic Acid SCHEMBL30437577 0.82 MLYCD (0.38) KDM4EALDH1A1FAAHPPARGPPARA
SCHEMBL30592836 0.81 GPR84 (0.34) ALDH1A1FAAHMEN1NR1I2LMNA
SCHEMBL30541526 0.78 ADA (0.40) FAAHTLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117447449-A PARP1 inhibitor and application thereof 南京圣和药业股份有限公司 2024-01-26 CN disclosed
EP-3954684-A1 PROCESS FOR THE PREPARATION OF HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS Ardelyx, Inc. (US) 2022-02-16 EP disclosed