Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122944 | 0.88 | HTT (0.66) | HTTPKMEPHX1TDP1WDR5 | |
| SCHEMBL29829398 | 0.88 | HTT (0.66) | HTTPKMEPHX1TDP1WDR5 | |
| SCHEMBL5505279 | 0.79 | CYP4F2 (0.54) | HTTPKMEPHX1TDP1ALDH1A1 | |
| SCHEMBL30743995 | 0.78 | ALDH1A1 (0.45) | HTTALDH1A1SMN1; SMN2GAAHIF1A | |
| SCHEMBL21305484 | 0.78 | ALDH1A1 (0.45) | HTTALDH1A1SMN1; SMN2GAAHIF1A | |
| SCHEMBL11689380 | 0.76 | PDGFRB (0.51) | HTTPKMTDP1WDR5ALDH1A1 | |
| SCHEMBL16094987 | 0.75 | ALDH1A1 (0.43) | HTTPKMALDH1A1SMN1; SMN2GAA | |
| SCHEMBL296681 | 0.75 | TDP1 (0.64) | HTTPKMTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL286591 | 0.74 | HTT (0.60) | HTTPKMEPHX1TDP1ALDH1A1 | |
| SCHEMBL25356037 | 0.74 | HSPB1 (0.58) | HTTTDP1ALDH1A1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |