Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.62 |
| ▸ | AKT2 | P31751 | 5/20 | 0.57 |
| ▸ | NT5C2 | P49902 | 2/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 2/20 | 0.56 |
| ▸ | PRKACG | P22612 | 2/20 | 0.56 |
| ▸ | PRKACB | P22694 | 2/20 | 0.56 |
| ▸ | NEK2 | P51955 | 2/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29761016 | 0.82 | TOP2A (0.54) | TOP2ANT5C2NT5EBRD4ROCK2 | |
| SCHEMBL2938675 | 0.80 | AKT2 (0.70) | AKT2NT5C2PRKACAPRKACGPRKACB | |
| SCHEMBL18486258 | 0.80 | AKT2 (0.70) | AKT2NT5C2NT5EPRKACAPRKACG | |
| SCHEMBL18486378 | 0.78 | TOP2A (0.49) | TOP2ANT5C2NT5ELIMK1MAPK1 | |
| SCHEMBL4939153 | 0.74 | LMNA (0.69) | TOP2ANT5C2NT5EPRKACABRD4 | |
| SCHEMBL28424527 | 0.73 | BRD4 (0.49) | TOP2AAKT2NT5C2NT5EPRKACA | |
| SCHEMBL29761047 | 0.71 | MTOR (0.51) | AKT2BRD4BRAF | |
| SCHEMBL30890069 | 0.70 | MAP2K4 (0.42) | TOP2ANPC1ALDH1A1LMNAHPGD | |
| SCHEMBL28753405 | 0.70 | AKT2 (0.60) | AKT2PRKACAPRKACGPRKACBNEK2 | |
| SCHEMBL1759307 | 0.70 | KMO (0.53) | NPC1ALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3130597-B1 | OLIGONUCLEOTIDE HAVING A NON-NATURAL NUCLEOTIDE AT THE 5'-TERMINAL | KYOWA KIRIN CO LTD (JP) | 2021-11-10 | — | — | EP | disclosed |
| US-10342819-B2 | Oligonucleotide having non-natural nucleotide at 5′-terminal thereof | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2019-07-09 | — | — | US | disclosed |
| US-20170354673-A1 | OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-12-14 | — | — | US | disclosed |
| EP-3130597-A1 | OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF | Kyowa Hakko Kirin Co., Ltd. (JP) | 2017-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10342819-B2 | Oligonucleotide having non-natural nucleotide at 5′-terminal thereof | RNGTT, UPF1, NSUN3 | TOP2A 409/4885AKT2 3555/4885NT5C2 26/4885 |
| US-20170354673-A1 | OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF | RNGTT, UPF1, NSUN3 | TOP2A 438/4885AKT2 3611/4885NT5C2 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.