Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31322342 | 0.78 | PARP1 (0.68) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL2015165 | 0.77 | LMNA (0.56) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Samoquasine A SCHEMBL15954512 | 0.76 | PARP1 (0.57) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL30482888 | 0.76 | LMNA (0.55) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL349009 | 0.73 | PARP1 (0.55) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL334691 | 0.73 | PARP1 (0.55) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL27983253 | 0.72 | PARP1 (1.00) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| Quinazolinone SCHEMBL88525 | 0.72 | PARP1 (1.00) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL12068009 | 0.72 | PARP1 (0.66) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL29130935 | 0.72 | PARP1 (0.53) | PARP1PDPK1CA12ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1978967-B1 | QUINAZOLINONE DERIVATIVES AS VANILLOID ANTAGONISTS | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | claimed |
| EP-1978967-B1 | QUINAZOLINONE DERIVATIVES AS VANILLOID ANTAGONISTS | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |