Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Methylatropine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.78 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.78 |
| ▸ | PABPC1 | P11940 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.97 |
| ▸ | BLM | P54132 | 4/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.78 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylatropine SCHEMBL34463463 | 0.99 | CHRM2 (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Methylatropine SCHEMBL824874 | 0.99 | CHRM2 (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Methylatropine SCHEMBL30647266 | 0.97 | BLM (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Methylatropine SCHEMBL1321572 | 0.97 | BLM (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Methylatropine SCHEMBL20798247 | 0.93 | SMN1; SMN2 (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Methylatropine SCHEMBL56394 | 0.93 | SMN1; SMN2 (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Methylatropine SCHEMBL30003811 | 0.93 | SMN1; SMN2 (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Ipratropium SCHEMBL3301405 | 0.89 | CHRM2 (0.98) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Atropine Oxide SCHEMBL98985 | 0.89 | CYP2C19 (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 | |
| Atropine Oxide SCHEMBL29369999 | 0.89 | CYP2C19 (1.00) | PABPC1CHRM2BLMSMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11246873-B2 | Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate | THE SCRIPPS RESEARCH INSTITUTE (US) | 2022-02-15 | — | — | US | disclosed |