Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16969045 | 0.92 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL16969046 | 0.87 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL15535154 | 0.85 | HPGD (0.38) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL15536492 | 0.84 | HPGD (0.41) | KDM4EALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL29391479 | 0.84 | HPGD (0.41) | KDM4EALDH1A1SMN1; SMN2GAAHPGD | |
| SCHEMBL15534880 | 0.84 | TP53 (0.39) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL15535850 | 0.79 | HPGD (0.37) | KDM4EALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL15535684 | 0.78 | MTNR1A (0.38) | ALDH1A1MAPTHPGDTSHR | |
| SCHEMBL15535598 | 0.78 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL15534883 | 0.77 | MEN1 (0.46) | KDM4EALDH1A1GAAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220047540-A1 | CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS | ORION CORP (FI) | 2022-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220047540-A1 | CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS | COMT, PNMT, HNMT | KDM4E 576/4885ALDH1A1 42/4885SMN1; SMN2 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.