Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.33 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL432680 | 1.00 | PIK3R1 (0.36) | PIK3R1PIK3CAASPHPIK3CDKCNQ3 | |
| SCHEMBL3840400 | 0.80 | PIK3R1 (0.42) | PIK3R1PIK3CAASPHPIK3CDKCNQ3 | |
| SCHEMBL30488644 | 0.78 | ASPH (0.36) | ASPHULK1CFTR | |
| SCHEMBL30433748 | 0.78 | PIK3R1 (0.38) | PIK3R1PIK3CAASPHPIK3CDKCNQ3 | |
| SCHEMBL1471015 | 0.78 | PIK3R1 (0.38) | PIK3R1PIK3CAASPHPIK3CDKCNQ3 | |
| SCHEMBL11919268 | 0.78 | ASPH (0.36) | ASPHULK1CFTR | |
| SCHEMBL16656835 | 0.75 | HPGD (0.35) | ASPHLRRK2CYP1A2ULK1CFTR | |
| SCHEMBL31214077 | 0.75 | PIK3CD (0.41) | PIK3R1PIK3CAASPHPIK3CDCFTR | |
| SCHEMBL28682675 | 0.75 | ASPH (0.34) | ASPHPIK3CDCYP11B1CYP11B2ULK1 | |
| SCHEMBL1440021 | 0.75 | PIK3CD (0.41) | PIK3R1PIK3CAASPHPIK3CDCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114072397-B | Heteroaryl aminopyrimidinamide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2025-03-28 | — | — | CN | disclosed |
| WO-2025054366-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | NICO THERAPEUTICS, INC. (US) | 2025-03-13 | — | — | WO | disclosed |
| CN-119241444-A | Aminopyrimidinamide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-119176782-A | Aminopyrimidinamide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2024-12-24 | — | — | CN | disclosed |
| CN-118930524-A | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-118878520-A | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-118878519-A | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-114258318-B | Aminopyrimidinamide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2024-09-20 | — | — | CN | disclosed |
| CN-114127057-B | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-111683662-B | Substituted pyrimidine compounds, pharmaceutical compositions and methods of treatment | 陈志宏 | 2024-04-02 | — | — | CN | disclosed |
| CN-112312905-B | Tetrazole-containing inhibitors of apoptosis signal-regulating kinase 1 and methods of use thereof | 英安塔制药有限公司 | 2024-03-15 | — | — | CN | disclosed |
| WO-2023185920-A1 | FAK DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BERRYBIO (SHANGHAI) LIMITED (CN) | 2023-10-05 | — | — | WO | disclosed |
| CN-116724044-A | Tri-heterocyclic compound, preparation method and application thereof | 上海湃隆生物科技有限公司 | 2023-09-08 | — | — | CN | disclosed |
| WO-2023040998-A1 | A CYCLIN-DEPENDENT KINASE INHIBITOR | Taizhou Eoc Pharma Co., Ltd. (CN) | 2023-03-23 | — | — | WO | disclosed |
| CN-113149996-B | Polycyclic amide derivative as CDK9 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-111995587-B | 1, 4-disubstituted 3, 4-dihydro-2 (3H) -quinazolinone compound and synthesis method and application thereof | 上海工程技术大学 | 2022-10-21 | — | — | CN | disclosed |
| CN-114258318-A | Aminopyrimidine amide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-114127057-A | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-114072397-A | Heteroaryl aminopyrimidine amide autophagy inhibitors and methods of use thereof | 德西费拉制药有限责任公司 | 2022-02-18 | — | — | CN | disclosed |