Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2277337 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAALOX5TSHRGSK3B | |
| SCHEMBL29846133 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAALOX5TSHRGSK3B | |
| SCHEMBL1361818 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAALOX5TSHRGSK3B | |
| SCHEMBL15783957 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAALOX5TSHRGSK3B | |
| SCHEMBL13560482 | 0.91 | TDP1 (0.44) | ALDH1A1ALOX5GSK3BROCK2CSF1R | |
| SCHEMBL15784058 | 0.91 | TDP1 (0.44) | ALDH1A1ALOX5GSK3BROCK2CSF1R | |
| SCHEMBL3772024 | 0.91 | TDP1 (0.44) | ALDH1A1ALOX5GSK3BROCK2CSF1R | |
| SCHEMBL18423157 | 0.90 | TDP1 (0.40) | ALDH1A1LMNAALOX5TSHRGSK3B | |
| SCHEMBL22437598 | 0.90 | TDP1 (0.40) | ALDH1A1LMNAALOX5TSHRGSK3B | |
| SCHEMBL18215736 | 0.90 | ALOX5 (0.45) | ALDH1A1LMNAALOX5TSHRGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117214338-B | Nidaminib ethanesulfonate cloth intermediate Z3Method for separating and detecting related substances in the same | 重庆华邦制药有限公司 | 2025-05-23 | — | — | CN | disclosed |
| EP-3747864-B1 | A METHOD FOR PREPARING METHYL (Z)-3-[[4-[METHYL[2-(4-METHYL-1-PIPERAZINYL)ACETYL]AMINO]PHENYL]AMINO]PHENYLMETHYLENE)-OXINDOLE-6-CARBOXYLATE (INTEDANIB, NINTEDANIB) | Midas Pharma GmbH (DE) | 2025-01-08 | — | — | EP | disclosed |
| CN-115703758-B | Compounds used as kinase inhibitors, preparation method and application thereof | 中国医学科学院药物研究所 | 2024-03-26 | — | — | CN | disclosed |
| CN-117214338-A | Nidaminib mesylate intermediate Z 3 Method for separating and detecting related substances in the same | 重庆华邦制药有限公司 | 2023-12-12 | — | — | CN | disclosed |
| CN-111465594-B | Synthesis of 2-indolinones known as intermediates for the preparation of Nidamibu | 费米有限公司 | 2023-11-07 | — | — | CN | disclosed |
| EP-3710427-B1 | SYNTHESIS OF A 2-INDOLINONE DERIVATIVE KNOWN AS INTERMEDIATE FOR PREPARING NINTEDANIB | FERMION OY (FI) | 2023-03-08 | — | — | EP | disclosed |
| US-11261158-B2 | Synthesis of 2-indolinone derivatives | FERMION OY (FI) | 2022-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11261158-B2 | Synthesis of 2-indolinone derivatives | AZI2, AANAT, IDO1 | ALDH1A1 99/4885LMNA 2714/4885ALOX5 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.