Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.56 |
| ▸ | HTR2A | P28223 | 7/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | HTR5A | P47898 | 2/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23270836 | 0.98 | KDM4E (0.57) | HTR1AHTR2AHTR6HTR5AHTR3E | |
| Hydrochloric Acid SCHEMBL31094011 | 0.98 | KDM4E (0.57) | HTR1AHTR2AHTR6HTR5AHTR3E | |
| Hydrochloric Acid SCHEMBL29433207 | 0.98 | KDM4E (0.57) | HTR1AHTR2AHTR6HTR5AHTR3E | |
| Hydrochloric Acid SCHEMBL294116 | 0.98 | KDM4E (0.57) | HTR1AHTR2AHTR6HTR5AHTR3E | |
| SCHEMBL24719283 | 0.94 | HTR1A (0.50) | HTR1AHTR2AHTR6HTR5AHTR3E | |
| SCHEMBL29433198 | 0.88 | DRD2 (0.57) | HTR1AHTR2AHTR2CDRD2 | |
| SCHEMBL14671117 | 0.88 | DRD2 (0.57) | HTR1AHTR2AHTR2CDRD2 | |
| SCHEMBL16449540 | 0.83 | DRD2 (0.50) | HTR1AHTR2AHTR2CDRD2 | |
| SCHEMBL23264479 | 0.82 | HTR2A (0.46) | HTR1AHTR2AHTR6HTR5AHTR3E | |
| SCHEMBL19258305 | 0.82 | HTR2C (0.42) | HTR1AHTR2AHTR6HTR5AHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 287 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118580229-B | Preparation method of bripiprazole | 湖南一格制药有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-118580229-A | Preparation method of bripiprazole | 湖南一格制药有限公司 | 2024-09-03 | — | — | CN | claimed |
| CN-117946066-A | Synthesis method of bripiprazole intermediate | 江苏宇锐医药科技有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-115677655-B | Synthesis method of epinastine intermediate | 湖南省湘中制药有限公司 | 2023-12-08 | — | — | CN | claimed |
| CN-114166960-B | Method for detecting substances related to epipiprazole | 西安远大科创医药科技有限公司 | 2023-09-29 | — | — | CN | claimed |
| CN-115677655-A | Synthesis method of brexpiprazole intermediate | 湖南省湘中制药有限公司 | 2023-02-03 | — | — | CN | claimed |
| CN-114166960-A | Detection method of brexpiprazole related substance | 西安远大科创医药科技有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-112079812-B | Prazoles antipsychotic key intermediate and electroreduction method thereof | 浙江大学 | 2021-08-06 | — | — | CN | claimed |
| EP-3397636-B1 | PROCESS FOR THE PREPARATION OF QUINOLINE-2(1H)-ONE DERIVATIVES | HONOUR R&D (IN) | 2021-08-04 | — | — | EP | claimed |
| US-10597386-B2 | Process and intermediates for the preparation of benzo[b]thiophene compounds | CRYSTAL PHARMA, S.A.U. (ES) | 2020-03-24 | — | — | US | claimed |
| US-10358440-B2 | Process for the preparation of brexpiprazole and intermediates thereof | CADILA HEALTHCARE LIMITED (IN) | 2019-07-23 | — | — | US | claimed |
| US-20190177309-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2019-06-13 | — | — | US | claimed |
| EP-3487854-A1 | THE METHOD FOR MANUFACTURE OF BREXPIPRAZOLE, INTERMEDIATES USED IN THIS METHOD, AND THE METHOD FOR MANUFACTURE THEREOF | Adamed Pharma S.A. (PL) | 2019-05-29 | — | — | EP | claimed |
| WO-2019073481-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND ITS INTERMEDIATES | INDOCO REMEDIES LIMITED (IN) | 2019-04-18 | — | — | WO | claimed |
| US-20190040048-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS | CURIA SPAIN, S.A.U. (ES) | 2019-02-07 | — | — | US | claimed |
| EP-3356342-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS | Crystal Pharma, S.A.U. (ES) | 2018-08-08 | — | — | EP | claimed |
| WO-2018087775-A1 | PROCESSES FOR THE PREPARATION OF 7-{4-[4-(1-BENZOTHIOPHEN-4-YL)PIPERAZIN-1-YL]BUTOXY}QUINOLIN-2(1H)-ONE | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2018-05-17 | — | — | WO | claimed |
| WO-2018015354-A1 | THE METHOD FOR MANUFACTURE OF BREXPIPRAZOLE, INTERMEDIATES USED IN THIS METHOD, AND THE METHOD FOR MANUFACTURE THEREOF | ADAMED SP. Z O.O. (PL) | 2018-01-25 | — | — | WO | claimed |
| US-20170320862-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2017-11-09 | — | — | US | claimed |
| EP-3150591-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS | Crystal Pharma S.A.U (ES) | 2017-04-05 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177309-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CYP4Z1, CYP4X1, CYP4B1 | HTR1A 251/4885HTR2A 256/4885HTR6 739/4885 |
| US-10358440-B2 | Process for the preparation of brexpiprazole and intermediates thereof | CYP4Z1, CYP4X1, CYP4B1 | HTR1A 251/4885HTR2A 256/4885HTR6 739/4885 |
| US-20170320862-A1 | PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF | CYP4Z1, CYP4X1, CYP4B1 | HTR1A 251/4885HTR2A 256/4885HTR6 739/4885 |
| US-20190040048-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS | CYP4X1, CYP2B6, CYP2C19 | HTR1A 145/4885HTR2A 216/4885HTR6 126/4885 |
| US-10597386-B2 | Process and intermediates for the preparation of benzo[b]thiophene compounds | CYP4X1, CYP2B6, CYP2C19 | HTR1A 145/4885HTR2A 216/4885HTR6 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.